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Volume 20
International Journal of Emergency Mental Health & Human Resilience
World Mental Health 2018
July 16-18, 2018
July 16-18, 2018 Dubai, UAE
Public Mental Health and Neuroscience
29
th
International Conference on
Stem Cells (SC) therapy as an emerging therapy in neurology
Saeed Shahbeigi
University of Tehran, Iran
S
temCells(SC)therapyemergesasapotentialnewhopeforneurologicalpatientsasitcouldaccomplishtheimmunomodulatory
as well as the neuroprotective functions. There is a growing body of literature that supports the potential of the SC for
immunomodulation and re-myelination. Here we focus on examining the registered published and on-going clinical trials
using stem cells especially the Mesenchymal Stem Cell (MSC) therapy in neurological disorders such as MS, ALS, Stroke,
spinal cord injuries and also some types of devastating neuropathies like POEMS. There are evidence showing that the MSC
can alter the phenotype of NK cells and suppress proliferation, cytokine secretion, and cytotoxicity against HLA-class I-
expressing targets. Some of these effects require cell-to-cell contact, whereas others are mediated by soluble factors, including
transforming growth factor-beta1 (TGFbeta1) and prostaglandin E2, pointing to the existence of diverse mechanisms for the
MSC-mediated NK-cell suppression . The MSC have been reported to block the differentiation of monocytes into dendritic cells
(DC) and impair antigen presentation as well as IL-12 production. Also the human MSC (hMSC) alter cytokine secretion and
induce more anti-inflammatory responses. Specifically, the hMSC by induction of mature dendritic cells (DC) decrease tumor
necrosis factor alpha (TNF-alpha) secretion and increase IL-10 secretion . The hMSC inhibit Th1 cells, decrease interferon
gamma, and affect Th2 cells by increasing secretion of IL-4. This causes an increase in the proportion of T- Regulatory cell
switches the CD4+ T cell responses from a Th1 to a Th2 polarized phenotype resulting in a decrease secretion of IFN-gamma
from NK cells. Generally speaking we are going to discuss the immunomodulatory effects of the mesenchymal stem cells and
finally to review some interested data from our experience and other papers around the world.
Biography:
Saeed Shahbeigi is a Neuroimmunology fellow fromUBCDivision of Neurology, Department of Medicine, Vancouver, Canada.
He is an author for Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis: An Overview of Open Labels and Ongoing
Studies. J Neurol Neurophysiol.
S_shahbeigi@yahoo.comSaeed Shahbeigi, Int J Emerg Ment Health 2018, Volume 20
DOI: 10.4172/1522-4821-C2-014