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Volume10, Issue 12 (Suppl) J Proteomics Bioinform, an open access journal
ISSN: 0974-276X
Page 49
conferenceseries.com
World Biomarkers & Pharma Biotech 2017
December 07-09, 2017
December 07-09, 2017 | Madrid, Spain
&
20th International Conference on
PHARMACEUTICAL BIOTECHNOLOGY
9th WORLD BIOMARKERS CONGRESS
JOINT EVENT ON
Usage of metabolomics profile as biomarkers itself for diagnostic diseases
P G Lokhov and A I Archakov
Institute of Biomedical Chemistry, Russia
Recently, the researches to find proteins as biomarkers of various diseases have become widespread. Especially these studies are
popular in оncology. However, until now proteins specific for cancer cells are not detected. In spite of it, to diagnose cancer
diseases biomarkers which are specific for a neoplastic process generally are widely used (such as CA-125, CA 19-9, CA 15-3, PSA,
α-fetoprotein etc.). However, they can’t discharge the main task: to diagnose the initial stages of disease, because their opportunity is
limited by low sensitivity of existing laboratory technologies. The situation is much better in the case of using RNA’s as biomarkers,
because PCR takes off such restrictions. In the case of metabolomic diagnostics there are the same concentration limits as in
proteomics. Therefore, it was decided not to use separate low molecular weight compounds as biomarkers but the whole metabolomic
profile of the sick person as a biomarker itself of a disease. With this purpose, at the first stage that profile was clusterized using the
method of principle component analysis to detect clusters of metabolites which are different from the clusters of healthy person.
At the second stage, the specificity and sensitivity of the proposed technology was evaluated using the SVM and ROC analyses, for
diagnostics of lung, prostate and other cancers.
Biography
P G Lokhov is the Head of Laboratory for Mass Spectrometry-based Medical Metabolomics in the Department of Proteomic Research and Mass Spectrometry of
IBMC, a position he has held since 2012. He is mainly interested in mass spectrometry-based metabolomics and proteomics, and their application for diagnostics.
He graduated from the 2nd Moscow Medical Institute, took the post-graduate course and thereafter received a PhD degree in Biochemistry in 2002. During his
career Dr. Lokhov has received several awards, including the State Prize of the Government of Russia.
PG Lokhov et al., J Proteomics Bioinform 2017, 10:12(Suppl)
DOI: 10.4172/0974-276X-C1-109