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conferenceseries
.com
10
th
International Conference on
February 22-23, 2018 | Paris, France
Vascular Dementia
Volume 8
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Vascular Dementia 2018
February 22-23, 2018
Obesity impairs memory and hippocampal post-synaptic structure in chronic cerebral hypoperfusion
in rats: Failure of compensatory mechanism
Yoon Ju Kim
and
Youn-Jung Kim
Kyung Hee University, Republic of Korea
O
besity is continuously increasing worldwide, and this trend is considered as obesity pandemic. The reason for focusing on
obesity as a major health problem is that it causes various diseases such as metabolic diseases and cardiovascular diseases.
As one of them, vascular dementia was reported to be high prevalence in obese population, which was associated with obesity-
related insulin resistance or oxidative stress. Thus, previous studies focused on the obesity as a risk factor; however, there were
few researches the effect of obesity on disease progression. To confirm the pathological changes in obese vascular dementia,
obesity was induced by high-fat diet (HFD) feeding and then, vascular dementia model was preceded with biliateral common
carotid artery occlusion (BCCAO) procedure in rats. After six weeks of the procedure, HFD+BCCAO exhibited worse memory
performances in Morris water maze test (p<.05) and radial arm maze test (p<.05) than BCCAO. In addition, post-synaptic
density-95 in hippocampus were significantly decreased in HFD+BCCAO than BCCAO (p<0.05). We confirmed that obesity
aggravated memory impairment with disruption of post-synaptic proteins. On the other hand, brain-derived neurotrophin
factor, phospho-extracellular signal-regulated kinase (p-ERK) and phospho-cAMP response element binding protein (p-CREB)
was respectively increased in BCCAO (all p<0.05) more than Sham, but HFD+BCCAO (all p<0.05) showed lowest expression
level. As a result, the decrease of BDNF, ERK and CREB in HFD+BCCAO, which are related to promote protein synthesis in
neuronal dendrites, suggests interruption of a compensatory mechanism in BCCAO procedure. It is first finding that obesity
exacerbates memory with damaged post-synaptic structure via disrupting BDNF-ERK-CREB compensatory mechanism. It is
suggested that obesity should consider as an aggravating factor in vascular dementia and we should keep focusing on weight
control in patient.
Biography
Yoon Ju Kim is a Registered Nurse (RN) in South Korea. She has completed her Master of Nursing degree and she is currently a PhD student with a major in
Biological Nursing Science at Kyung Hee University.
lc_or@naver.comYoon Ju Kim et al., J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C1-037