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Volume 8 Journal of Traditional Medicine & Clinical Naturopathy
Page 20
conference series.com
June 20-21, 2019 Dubai, UAE
Joint Meeting on
&
2nd World Congress on Traditional & Complemenatry Medicine
2nd International Conference on Herbal & Traditional Medicine
Traditional Med Meet 2019 &
Herbal Traditional 2019
June 20-21, 2019
Leptadenia hastata leaf extracts reduce bodyweight gain and improve insulin sensitivity in two
animal models of obesity and insulin resistance
Aim: Leptadenia hastata (LH), an edible vegetable andmedicinal plant used traditionally in sub-SaharanAfrican
countries for various diseases. The potential anti-obesity and anti-diabetic effects of aqueous and methanol leaf
extracts of LH in high fat diet-induced obese mice and leptin-deficient (ob/ob ) mice are investigated.
Methods: C57Bl/6 female mice fed 60% High Fat Diet (HFD) and leptin-deficient (ob/ob) male mice (fed
chow diet) were treated for six weeks with 250 -1 of LH aqueous or methanol extracts. The time course of
changes in food intake, body weight, body fat, energy expenditure, blood glucose and plasma levels of insulin
and leptin (for HFD mice) were determined. In vitro effects of both extracts on lipolysis and lipogenesis were
also investigated.
Results: In HFD animals, both extracts resulted in a significant reduction (p<0.05) in body weight (16.6%
and 18.7%) and food intake (10% and 11%) with a significant increase in 24 hrs. energy expenditure (53.3 and
61.4%). These effects were coupled with a significant decrease in fat mass (p<0.05) and in plasma leptin levels
(2.8 and 3.5 fold change). Both extracts also improved (p<0.05)-glucose tolerance and reduced fasted blood
glucose and plasma insulin levels. Consequently, HOMA-IR was reduced by 65% (compared to control group).
In ob/ob mice, the chronic treatment with methanol extract resulted in a significant reduction in cumulative
body weight gain (p<0.001), an improvement in both oral glucose and insulin tolerance tests (p<0.01 and
p<0.001, respectively) and a decrease in fasted plasma insulin by 64%. In vitro, the LH extracts decreased
lipogenesis in human pre-adipocytes and increased lipolysis in mouse primary adipocytes.
Conclusion: LH would be beneficial as a dietary supplement in the treatment of obesity and insulin resistance
related to high fat diet consumption, acting via a reduction of food intake and fat mass and an elevation of
energy expenditure and improvement of insulin sensitivity.
Biography
Mohamed S Zaibi has pursued his BSc in Biochemistry and MSc in Nutrition and Human Physiology from the School of Sciences and his PhD
from Medical School (Dijon, France), where he worked on the effect of oral anti diabetic drugs on hepatic protein metabolism regulation. He
is the Associate Director at the School of Postgraduate Medicine & Allied Health and is the Head of BITM.
Mohamed S Zaibi
The University of Buckingham, UK
Mohamed S Zaibi, J Tradit Med Clin Natur 2019, Volume 8