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Volume 5

Toxicology: Open Access

Toxicology Congress 2019

May 06-07, 2019

May 06-07, 2019 Tokyo, Japan

World Congress on

Toxicology and Pharmacology

Toxicol Open Access 2019, Volume 5

DOI: 10.4172/2476-2067-C1-009

Blood lymphocytes cytotoxicity monitoring of hospital nurses occupationally exposed to anti-neoplastic

drugs

Maral Ramezani, Jalal Pourahmad Jaktaji and J Shahid Beheshti

Iran University of Medical Sciences, Iran

nti-neoplastic agents are extremely active biological compounds and their action is non-selective. Oncology nurses are

exposed at the workplace to a wide spectrum of these agents in sub therapeutic concentrations might face unknown

biological consequences which are always a serious health problem. The purpose of this study is to assess biological and

cellular alteration in blood lymphocytes of nurses who work in chemotherapy wards and compare the obtained data to those

of nurses who work in other wards. All nurses who work in chemotherapy wards were selected with enter and exit criteria

clarified by medical and para medical tests. Demographic data such as age, sex, time of exposure, smoking status and alcohol

drinking were collected and blood samples were taken. Control nurses who work in other wards of hospitals were chosen

by the same criteria imposed for oncology nurses. All cytotoxicity parameters (cell viability, ROS formation, MMP collapse,

lysosomal membrane damage, lipid peroxidation, caspase 3 activity and apoptosis phenotype) in exposed oncology nurses were

significantly (p<0.001) higher than those of unexposed control nurses. Our results indicate that the lymphocytes of oncology

nurses exposed to anti-neoplastic drugs are more susceptible to oxidative stress than controls group. Hence, we should prevent

hospital oncology nurse from contacting with possible risks such as inhalation of aerosols, particles and droplets via. direct

skin or eyes contact by spraying, swallowing of chemotherapeutic agents due to poor health conditions or dispersal of anti-

cancer drug, or injection as a result of scarring by the sharp tools.