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Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Natural products as drug leads for neurodegenerative diseases; Alzheimer and Dementia
Heba Handoussa, Reham Wagdy, Alaa Selim, Reham AbdelKader, Nabila Hamdi and Nesreen El Sayed
German University in Cairo, Egypt
Statement of the Problem: Alzheimer’s disease (AD) and Dementia are multifactorial neurodegenerative disorders driven
by various pathogenic events with neuroinflammation and oxidative stress. Phenolics are widely known for their different
beneficial characteristics, they could be considered as promising therapeutic agents against neurodegenerative diseases.
Aim: The purpose of this study is to evaluate the potential effect of some Egyptian medicinal plants; Bauhinia variegate (Bv)
and Egyptian Nutraceuticals; Corchorus olitorius (Co) & Majorana hortensis (Mh) to ameliorate neuroinflammation and
amyloidogenesis accompanied by these neurodegenerative diseases.
Methodology & Theoretical Orientation: Several parameters were used to evaluate the phenolic content in these medicinal
plants; cognitive impairment via assessment of neurobehavioral tests, neuroinflammation and oxidative stress which are
characteristic features of neurodegenerative diseases.
Findings: Bauhinia variegata showed significant improvement in neurobehavioral even with the least dose studied; 50 mg/
kg in Y-maze through enhancing mean % alternation by 57.55% and reduction in Aβ42 levels was observed with same dose
of 39.89% and increment of superoxide-dismutase level by 80% while Corchorus olitorius & Majorana hortensis significantly
improved recognition memory that was shown to be altered in the LPS group and COX-2 inflammatory markers were reduced
by (CO) and (Mh) compared to the LPS group proven by
immunohistochemistry investigation.
Conclusion & Significance: These findings suggest that
phenolics within these medicinal plants may be useful
in protection against Dementia and neuroinflammation
through enhancement of cognition and limiting
neurodegeneration and modulating the proinflammatory
pathway.
Recommendations: The high edible phenolics intake
could be prophylactically protective against several
neurodegenerative diseases.
Recent Publications :
• Sobeh M, ElHawary E, Labib R, Handoussa H and Ayoub N (2016) Identification of phenolic secondary metabolites from
Schotia brachypetala Sond. (Fabaceae) and demonstration of their antioxidant activities in Caenorhabditis elegans. PeerJ,
PubMed 27896020.
• Farag M, Handoussa H, Fekry MI, Wessjohann LA (2016) Metabolite profiling in 18 Saudi date palm fruit cultivars and
their antioxidant potential via UPLC-qTOF-MS and multivariate data analyses. Food Function 7 (2): 1077-86.
• Handoussa H, Mandour Y, Swilam N Hanafi R and Mahran L (2015) Structural docking studies of COX-II inhibitory
activity for quercetin metabolites derived from Corchorus Olitorius and Vitis Vinifera. International Journal of Food
Properties 2377-2384.
• Yara Hassaan Y, Handoussa H, El-Khatib A, Linscheid M, Sayed N and Ayoub N (2014) Evaluation of plant phenolic
metabolites as a source of Alzheimer's drug leads biomed research international. Article ID 843263.
• Handoussa H, Hanafi R, Eddiasty I, El-Gendy M, Linscheid M, Mahran L and Ayoub N (2013) In vitro and in vivo anti-
inflammatory and cytotoxic capacities of dietary phenolics isolated from Corchorus olitorius and Vitis vinifera. Journal of
Functional Foods 5 (3): 1204-1216.
Heba Handoussa et al., Toxicol Open Access 2017, 3:1 (Suppl)