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conferenceseries.com
Volume 10, Issue 8 (Suppl) J Proteomics Bioinform, an open access journal
ISSN: 0974-276X Structural Biology 2017
September 18-20, 2017
9th International Conference on
Structural Biology
September 18-20, 2017 Zurich, Switzerland
Arieh Zaritsky, J Proteomics Bioinform 2017, 10:8(Suppl)
DOI: 10.4172/0974-276X-C1-0100
Is nucleoid complexity hence cell diameter limited by the eclipse?
Arieh Zaritsky
Ben-Gurion University of the Negev, Israel
Cell widthWof Escherichia coli is correlated with the mean complexity of its nucleoid, which is expressed as the ratio between
the mean times to replicate it and to duplicate the cell aka the number of replication positions n. A set of old, puzzling
observations of cell size and dimensions is qualitatively consistent with the view that W is determined by n, and that branching
results from breaching a maximum possible value. This maximum nmax is interpreted in terms of a minimal distance possible
between successive moving replisomes, so-called eclipse. The data is subject to analytical quantification designed to model the
correlations in a way that may (1) shed light on the necessary coupling between the two unique structures in a bacterial cell,
nucleoid and sacculus, and (2) lead to decipher the primary signal transduced from DNA to the peptidoglycan biosynthetic
pathway. The first approximation is not sufficient to account for the rate at which average cell size rises with time (Po-Yi H and
Amir A, personal communication), hence two additional causes are considered to reconcile this discrepancy: loss of division
capacity of some DNA-less cells and dependence of the time needed for division on W. A physical signal is invoked, related to
transcription/translation of membrane protein genes coupled to membrane-insertion of these proteins termed "transertion",
but means to measure the reciprocal stress imposed by transertion strings on both nucleoid and cell envelope are sorely lacking.
Biography
Arieh Zaritsky of Ben-Gurion University's Faculty of Natural Sciences runs a laboratory investigating parallel fields, pure and applied.
During his career at BGU (1973-todate), Dr. Zaritsky has instructed over 50 trainees (graduate students and scientists) and was awarded numerous research
grants, allowing him to study both fields of expertise. He visited many higher education Institutions around the world and delivered invited lectures related to both
research fields at international meetings. After obtaining a distinguished MSc in Genetics at The Hebrew University of Jerusalem (1967), he graduated at Leicester
University (1971) and post-doc'ed at The Copenhagen's Institute of Microbiology (1972). Professor Zaritsky is a recognized expert on bacterial cell physiology
and bacteriophage multiplication and published over 130 peer-reviewed articles ). Dr. Zaritsky Chaired BGU's Life Sciences
department (1989-1991) and is an Editorial Board member of Bioengineered and awardee of 1994 Burroughs-Wellcome/ASM Visiting Professorship.