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Volume 8
Journal of Stem Cell Research & Therapy
ISSN: 2157-7633
Stem Cell Congress 2018
October 08-09, 2018
October 08-09, 2018 | Zurich, Switzerland
10
th
Annual Conference on
Stem Cell & Regenerative Medicine
Regeneration of infarcted myocardium using activated adult stem cells
Cai Dongqing
Jinan University, China
R
egeneration of infarcted myocardium is still a big challenge in clinic. Stem cell therapy has shed light to regenerate the
infarcted myocardium. However, low survival rate of transplanted stem cells and very low terminal differentiation of
transplanted stem cells limit therapeutic effects of stem cells to achieve functional and structural regeneration of infarcted
myocardium. Recently our lab developed a novel activated adult stem cell therapy for infarcted myocardium. We applied bio-
activated strategy to pre-activate adult endogenous cardiac stem cells and adult bone narrow stem cells and then transplanted
into infarcted myocardium in rat model. We found that these novel adult stem cell therapies were able to decrease the infarct
size and improve the myocardial function significantly. Importantly, the therapeutic effect of this novel therapy is more effective
than non-activated stem cells. Our finding suggested that this novel strategy might be considered as novel stem cell therapy for
us to further develop the novel approach to regenerate infarcted myocardium.
Biography
Cai Dongqing completed M D at Guangzhou Medical College in 1987, PhD at The Chinese University of Hong Kong in 2000, Postdoctoral Associate at Weill Medical
College of Cornell University, USA in 2000-2003. He works as a Professor and Director at Key Laboratory of Regenerative Medicine, Ministry of Education, Jinan University.
He is a Director at Department of Developmental and Regenerative Biology, Jinan University. His Scientific interests are Aging and microenvironment in regeneration of
myocardial infarction (MI); Cardiac vascular specific targeting and therapy (stem cell and therapeutic angiogenesis) for MI; Aging and regeneration of Tissue & Organ. He
published 40 SCI papers. Grant: 2003 - present: The Major Research plan of the National Natural Science Foundation of China-Key program, National Key R&D Program
of China, 863, International collaboration grant of Ministry of Science & Technology, Seven NSFC-grants, etc.
tdongbme@jnu.edu.cnCai Dongqing, J Stem Cell Res Ther 2018, Volume 8
DOI: 10.4172/2157-7633-C4-041