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conferenceseries.com
March 20-22, 2017 Orlando, USA
3rd International Conference on
Smart Materials & Structures
Volume 6, Issue 2 (Suppl) J Material Sci Eng
ISSN: 2169-0022 JME, an open access journal Smart Materials 2017
March 20-22, 2017
Nano-biocomposites for biomedical application
Igor Y Denisyuk1, Natalia V Vasilyeva2, Mari Iv Fokina1, Maya V Uspenskaya1, Julia E Burunkova1, Natalia A Zulina2, Tatiana S Bogomolova2, Irina V
Vybornova2, Aleksandr S Stepanov2 and Elena A Orishak2
1ITMO University, Russia
2I. Metchnikov North-Western State Medical University, Russia
Silver, gold, selenium and metal oxides nanoparticles in polymer matrix intensively investigated in biomedical application due to
the plenty of unique properties of antimicrobial properties to Gram-positive, Gram-negative pathogens and antifungal activity
is an important scientific problem to create bio-nanocomposites. Non-selective, broad spectrum antibacterial and antifungal
activity against different types of microorganisms as well as the long-term effect for a few months is one of the main requirements
to biopolymers. Nanocomposites with nanoparticles Ag, Au, SiO2, ZnO were prepared on the basis of two monomer compositions:
(1) Acidic composition consisting of monomers: 2-Carboxyethyl and Bisphenol A glycerolate. (2) pH neutral formulation
consisting of monomers: Diurethanedimethacrylate and Isodecyl acrylate and photo initiator. Methods of preparing polymer films
based nanocomposites can be found in our papers. Exposure was increased 5 times from total time of polymerization for these
composites; prepared samples were heated at 50oC for 12 hours to minimize the effects of residual monomers in the experiment.
As test objects were used: Strains of fungi Candida albicans (С. albicans NCTC 885-653) and Aspergillus fumigatus (clinical isolate);
strains of staphylococci Community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA, penicillin-binding protein
(PBP2α) - positive); Healthcare-associated Methicillin-resistant Staphylococcus aureus (HA-MRSA, penicillin-binding protein
(PBP2α) - positive); Methicillin-resistant Staphylococcus epidermidis (MRSE, penicillin-binding protein (PBP2α) - positive);
Methicillin-resistant Staphylococcus epidermidis (MRSE, penicillin-binding protein (PBP2α) - negative); Methicillin-resistant
Staphylococcus aureus (MRSA, penicillin-binding protein (PBP2α) -negative); Methicillin-susceptible Staphylococcus aureus (MSSA);
Methicillin-susceptible Staphylococcus epidermidis (MSSE). The antifungal activity of ZnO nanocomposites based on polymeric
matrix 2-Carboxyethyl acrylate/Bisphenol-A-glycerolate (1 glycerol/phenol) diacrylate against C. albicans and A. fumigatus was
found. Pronounced suppressive effect of ZnO nanocomposites based on polymeric matrix 2-Carboxyethyl acrylate/Bisphenol-A-
glycerolate (1 glycerol/phenol) diacrylate against staphylococci was identified. The antifungal activity of polymeric matrix based on
2-Carboxyethyl acrylate/Bisphenol-A-glycerolate (1 glycerol/phenol) diacrylate against C. albicans was found.
Biography
Igor Y Denisyuk has his expertise in field of nanoparticles, non-linear molecular crystals, polymer material, photonics, phodegradable nanocomposites and
biomedical nanocomposites.
Igor Y Denisyuk et al., J Material Sci Eng 2017, 6:2 (Suppl)