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Page 37
Notes:
conferenceseries
.com
March 20-22, 2017 Orlando, USA
3
rd
International Conference on
Smart Materials & Structures
Volume 6, Issue 2 (Suppl)
J Material Sci Eng
ISSN: 2169-0022 JME, an open access journal
Smart Materials 2017
March 20-22, 2017
Nano-biocomposites for biomedical application
Igor Y Denisyuk
1
, Natalia V Vasilyeva
2
, Mari Iv Fokina
1
, Maya V Uspenskaya
1
, Julia E Burunkova
1
, Natalia A Zulina
2
, Tatiana S Bogomolova
2
, Irina V
Vybornova
2
, Aleksandr S Stepanov
2
and
Elena A Orishak
2
1
ITMO University, Russia
2
I. Metchnikov North-Western State Medical University, Russia
S
ilver, gold, selenium and metal oxides nanoparticles in polymer matrix intensively investigated in biomedical application due to
the plenty of unique properties of antimicrobial properties to Gram-positive, Gram-negative pathogens and antifungal activity
is an important scientific problem to create bio-nanocomposites. Non-selective, broad spectrum antibacterial and antifungal
activity against different types of microorganisms as well as the long-term effect for a few months is one of the main requirements
to biopolymers. Nanocomposites with nanoparticles Ag, Au, SiO
2
, ZnO were prepared on the basis of two monomer compositions:
(1) Acidic composition consisting of monomers: 2-Carboxyethyl and Bisphenol A glycerolate. (2) pH neutral formulation
consisting of monomers: Diurethanedimethacrylate and Isodecyl acrylate and photo initiator. Methods of preparing polymer films
based nanocomposites can be found in our papers. Exposure was increased 5 times from total time of polymerization for these
composites; prepared samples were heated at 50
o
C for 12 hours to minimize the effects of residual monomers in the experiment.
As test objects were used: Strains of fungi
Candida albicans (С. albicans
NCTC 885-653) and
Aspergillus fumigatus
(clinical isolate);
strains of staphylococci Community-associated Methicillin-resistant
Staphylococcus aureus
(CA-MRSA, penicillin-binding protein
(PBP2α) - positive); Healthcare-associated Methicillin-resistant
Staphylococcus aureus
(HA-MRSA, penicillin-binding protein
(PBP2α) - positive); Methicillin-resistant
Staphylococcus epidermidis
(MRSE, penicillin-binding protein (PBP2α) - positive);
Methicillin-resistant
Staphylococcus epidermidis
(MRSE, penicillin-binding protein (PBP2α) - negative); Methicillin-resistant
Staphylococcus aureus
(MRSA, penicillin-binding protein (PBP2α) -negative); Methicillin-susceptible
Staphylococcus aureus
(MSSA);
Methicillin-susceptible
Staphylococcus epidermidis
(MSSE). The antifungal activity of ZnO nanocomposites based on polymeric
matrix 2-Carboxyethyl acrylate/Bisphenol-A-glycerolate (1 glycerol/phenol) diacrylate against
C. albicans
and
A. fumigatus
was
found. Pronounced suppressive effect of ZnO nanocomposites based on polymeric matrix 2-Carboxyethyl acrylate/Bisphenol-A-
glycerolate (1 glycerol/phenol) diacrylate against staphylococci was identified. The antifungal activity of polymeric matrix based on
2-Carboxyethyl acrylate/Bisphenol-A-glycerolate (1 glycerol/phenol) diacrylate against
C. albicans
was found.
Biography
Igor Y Denisyuk has his expertise in field of nanoparticles, non-linear molecular crystals, polymer material, photonics, phodegradable nanocomposites and
biomedical nanocomposites.
denisiuk@mail.ifmo.ruIgor Y Denisyuk et al., J Material Sci Eng 2017, 6:2 (Suppl)
http://dx.doi.org/10.4172/2169-0022.C1.061