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Volume 4, Issue 7(Suppl) J Infect Dis Ther 2016
ISSN: 2332-0877, JIDT an open access journal Skin Diseases & Microbiology 2016
October 03-05, 2016
Page 22
Notes:
conferenceseries.com
Infectious Diseases, Diagnostic Microbiology &
Dermatologists Summit on Skin Infections
October 03-05, 2016 Vancouver, Canada
International Conference on
Cross talk between innate and adaptive immunity in infection
S ignificant progress has been made in recent years on our understanding of the interaction of innate and adaptive immune
responses in infectious diseases. Using a mouse model of chlamydial lung infections, we studied the role of natural killer
cells (NK) and NK T cells (NKT) on the function of macrophages, dendritic cells (DC), and T cells host resistance against
the infections. By gene knockout and antibody deletion techniques, we have shown significant changes of the phenotype and
function of DC, T cells and macrophages in the mice with NK or NKT cell deficiency, particularly the subsets of these cells.
More importantly, we demonstrate that the changes of phenotype, subset and function of these innate and adaptive immune
cells correlate with the susceptibility and pathology to chlamydial infections. The data suggest the critical importance of the
modulating effect of innate immune system on adaptive immunity in intracellular bacterial infections.
Biography
Xi Yang is a Canada Research Chair in Infection and Immunity. He is working as a Professor in the departments of Medical Microbiology and Immunology of
University of Manitoba, Canada. He is also extending his duties as a Chair of Promotion and Tenure committee in the department of Immunology. The research
program in his laboratory focuses on the cellular and molecular basis of immune responses to allergens and infectious agents and on the development of
immunoprophylactic approaches for allergy and infectious diseases.
Xi Yang
University of Manitoba, Canada
Xi Yang, J Infect Dis Ther 2016, 4:7(Suppl)