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Respiratory Medicine 2016
October 17-18, 2016
Volume 6, Issue 5(Suppl) J Pulm Respir Med
ISSN: 2161-105X JPRM, an open access journal
conferenceseries .com
October 17-18, 2016 Chicago, USA
Respiratory and Pulmonary Medicine
2nd International Conference on
Anne-Marie Ionescu et al., J Pulm Respir Med 2016, 6:5(Suppl)
Hemoptysis and a purpuric rash: A rare presentation of amyloidosis
Anne-Marie Ionescu and Christine O’Brien
George Eliot Hospital, UK
Amiddle aged man was admitted with a 2-3 year history of recurrent hemoptysis on exertion, culminating in a requirement
for home oxygen therapy. On examination, he had a diffuse purpuric rash, subconjunctival hemorrhages, oral ulcers,
macroglossia and dystrophic nails. He was initially investigated for connective tissue disease (CTD) as a cause of HRCT-
demonstrated lung fibrosis. However, further investigations found a lambda light-chain band on electrophoresis and a
plasma cell dyscrasia on flow cytometry. Serum amyloid protein (SAP) scan, dermatological biopsy and bone marrow biopsy
confirmed primary systemic amyloidosis secondary to multiple myeloma. It is believed that the cause of his hemoptysis is
amyloid deposition in the lungs, though the SAP scan and CT report did not confirm this. His cause of hemoptysis remained
controversial, though the clinical picture was one of amyloidosis. He underwent chemotherapy and clinically improved with
no further reports of hemoptysis, resolution of his dermatological features and now he no longer requires home oxygen. Our
aim is to promote the consideration of other potential causes of hemoptysis when in conjunction with other systemic features
of disease. We also aim to elaborate on our case’s recovery of his respiratory symptoms when the hematological diagnosis had
been targeted with relevant chemotherapy.
Biography
Anne-marie Ionescu has done BSc and MBBS from the University College London (UCL) Medical School in the year 2015.