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Respiratory Medicine 2016
October 17-18, 2016
Volume 6, Issue 5(Suppl) J Pulm Respir Med
ISSN: 2161-105X JPRM, an open access journal
conferenceseries .com
October 17-18, 2016 Chicago, USA
Respiratory and Pulmonary Medicine
2nd International Conference on
Varsha Kashaw et al., J Pulm Respir Med 2016, 6:5(Suppl)
Design, synthesis and anti-tubercular potential of some new substituted 1,2,4-triazoles derived from
isonicotinic acid hydrazides
Varsha Kashaw1, 2, Vaibhav Rajoriya1, Rakesh Kumar Jain1 and Sushil Kumar Kashaw2
1SVN University, India
2Dr Harisingh Gour University, India
Objective of the study was to design and synthesize some new substitutes of 1,2,4-triazoles derived from isonicotinic acid
hydrazides and screen for anti-tubercular activity. A series of new substituted 1,2,4-triazoles; isonicotinic acid hydrazide
derivative (1–28) were synthesized. Potassium dithiocarbazinate (1) was obtained from the reaction of isonicotinic acid
hydrazide with carbon disulfide in basic medium (KOH) and converted into 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-
thiol (2) by the treatment with hydrazine hydrate. The synthesis of the other compound was performed from the reaction of
(2) with seven different benzaldehyde resulted in the formation of 4-[(substituted phenyl)-methylene]-amino-5-(pyridine-4-
yl)-4H-1,2,4-triazol-3-thiol (3). The final compound synthesized from the reaction of 3 with four different acetanilide resulted
in the formation of 4-[substituted phenyl)-methylene]-amino-3- (N-substitutedcarboxamidomethylthio)-5-(pyridine-4-yl)-
4H-1,2,4-triazoles (4). The structures of the synthesized compounds (1-28) were characterized by IR, 1H NMR, 13C NMR,
mass spectroscopy and elemental method of analysis. IR data, 1HNMR spectra, 13C NMR spectra, mass spectra and elemental
analysis indicates that 28 compounds were synthesized as proposed. In conclusion, their biological activities and study for
toxicity are required.
Biography
Varsha Kashaw has completed her PhD in 2007 from Dr Harisingh Gour University, (A Central University; ‘A’ Grade by UGC-NAAC), India. Currently, she is working
at the Department of Pharmaceutical Sciences, SVN University, India as an Associate Professor. To her credit, she is handling two research projects which are
sponsored by State and Indian Government. She has published many research papers in the journals of great repute. At present she is pursuing her MBA from
Global University.