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Volume 7
OMICS Journal of Radiology
Radiology and Oncology 2018
July 16-17, 2018
July 16-17, 2018 Dubai, UAE
Radiology and Oncology
2
nd
World Congress on
Direct evidence of viral infection and mitochondrial alterations in the brain of fetuses at high risk for
schizophrenia
Segundo Mesa Castillo
Havana Psychiatric Hospital, Cuba
T
here is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences points towards the intra-
uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of
the brain of the fetus. The current available technology doesn't allow observing what is happening at cellular level since the
human brain is not exposed to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia. In
1977, we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic mothers in order
to find differences at cellular level in relation to controls. In these studies we have observed within the nuclei of neurons the
presence of complete and incomplete viral particles that reacted in positive form with antibodies to Herpes Simplex Hominis
type-I [HSV1] virus and mitochondria alterations. The importance of these findings can have practical applications in the
prevention of the illness keeping in mind its direct relation to the etiology and physiopathology of schizophrenia. A study of
amniotic fluid cells in women at risk of having a schizophrenic offspring is considered. Of being observed the same alterations
that those observed previously in the cells of the brain of the studied fetuses, it would intend to these women in risk of having
a schizophrenia descendant, previous information of the results, the voluntary medical interruption of the pregnancy or an
early anti HSV1 viral treatment as preventive measure of the later development of the illness.
segundo@infomed.sld.cuOMICS J Radiol 2018, Volume 7
DOI: 10.4172/2167-7964-C1-022