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Volume 8
J Community Med Health Educ, an open access journal
ISSN: 2161-0711
Public Health 2018
February 26-28, 2018
PUBLIC HEALTH AND NUTRITION
3
rd
World Congress on
February 26-28, 2018 London, UK
RED BLOOD CELL FOLATE CONCENTRATIONS AND CORONARY HEART DISEASE
PREVALENCE: A CROSS-SECTIONAL STUDY BASED ON 1999-2012 NATIONAL HEALTH
AND NUTRITION EXAMINATION SURVEY
Yang Peng
a
and
Zhiqiang Wang
a
a
The University of Queensland, Australia
Statement of the Problem
: Folate is involved in a number of metabolic pathways. Red blood cell (RBC) folate is a well-
established indicator of folate intake. However, studies focused on the association between RBC folate and coronary heart
disease (CHD) are limited. The aim of the current study is to investigate the effect of RBC folate concentrations on the presence
of CHD in a nationally representative sample of American adults.
Methodology & Theoretical Orientation
: We included 22499 participants of 1999-2012 National Health and Nutrition
Examination Survey (NHANES) aged 30 to 74 years with RBC folate concentrations, CHD status and responses to co-variates
questions. The status of CHD was self-reported. Bio-Rad Quanta Phase II radioassay and microbiological assay were used to
measure RBC folate concentrations. Firstly, we treated RBC folate as a categorical variable, based on RBC folate tertiles, and
used logistic regression analysis to display the RBC folate and CHD relationship. Secondly, we explored associations using a
combination of restricted cubic spline and logistic regression models, stratified by sex.
Findings
: 822 participants were self-reported CHD, with a prevalence of 3.65%. After adjusting for several well-established
traditional CHD risk factors, RBC folate was positively related to CHD presence in the total population and the association
was more pronounced among males than females. A J-shaped pattern was observed in RBC folate concentrations for females.
Conclusion & Significance
: Elevated RBC folate concentrations were associated with higher CHD risk. Further investigation
is needed to test the association in large-scale follow-up studies.
Biography
Yang Peng is currently a PhD student in the University of Queensland. He is now involved in evaluation the cardiovascular health, using seven American Health
Association defined modifiable factors and behaviors, in the general Australian adults. In addition, he is interested to explore the associations between several
biomarkers, like folate and C-reactive protein, and the presence and mortality of cardiovascular diseases.
y.peng@uq.edu.auYang Peng et al., J Community Med Health Educ 2018, Vol 8
DOI: 10.4172/2161-0711-C1-032