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conferenceseries
.com
Volume 20, Issue 7 (Suppl)
J Psychiatry
ISSN: 2378-5756 JOP, an open access journal
Psychiatry and Mental Health 2017
November 20-21, 2017
November 20-21, 2017 Melbourne, Australia
28
th
International Conference on
Psychiatry and Mental Health
Genetic variants in
OXTR
gene and childhood physical abuse collaborate to modify the risk of
aggression in Chinese adolescents
Yizhen Yu, Yanmei Zhang, Chunxia Wu, Hongjuan Chang, Qiuge Yan, Linguo Wu, Shanshan Yuan, Jingjing Xiang, Wen Hao and Yanmei Zhang
Huazhong University of Science and Technology, China
Introduction & Objective:
Accumulating evidence suggests that genetic and environmental factors may influence aggression
susceptibility. Compared to some extensively studied candidate genes of aggression, very little is known about the
OXTR
gene.
The objective of this study was to determine whether genetic variants in the
OXTR
gene were associated with aggression
risk and whether the polymorphisms would show interactive effects with childhood maltreatment on aggressive behavior in
Chinese adolescents.
Methods:
A total of 996 participants including 488 cases and 488 controls were selected in our study. Aggression, childhood
maltreatment was measured by self-reported questionnaire. Buccal cells of all subjects were collected. Genotyping was
performed using SNPscan. We explored both main effects of
OXTR
polymorphisms, as well as interactive effects between the
polymorphisms and childhood maltreatment on aggressive behavior.
Results:
Participants who carried the rs237885 TT genotypes in
OXTR
gene had a higher risk of aggression compared to
those who carried GG or GT genotypes under the recessive model (OR=1.40, 95% CI, 1.04-1.89) after controlling for potential
confounders. In addition, we also found that the polymorphismhad a synergic additive interactionwith childhood physical abuse
on the aggression risk. The synergy index (S), the Attributable Proportion due to interaction (AP) and the Relative Excess Risk
due to Interaction (RERI) were 2.81 (95% CI, 1.37-5.77), 0.59 (95% CI, 0.33-0.84) and 6.69 (95% CI, 0.41-12.96), respectively.
Conclusion:
The present study provides evidence that genetic variants of
OXTR
may contribute to the susceptibility of
aggression. Moreover, this is the first study reporting significant interactive effects of
OXTR
polymorphism and childhood
physical abuse on aggressive behavior in Chinese adolescents.
yuyizhen650@163.comYizhen Yu et al., J Psychiatry 2017, 20:7 (Suppl)
DOI: 10.4172/2378-5756-C1-030