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conferenceseries
.com
Volume 20, Issue 7 (Suppl)
J Psychiatry
ISSN: 2378-5756 JOP, an open access journal
Psychiatry and Mental Health 2017
November 20-21, 2017
November 20-21, 2017 Melbourne, Australia
28
th
International Conference on
Psychiatry and Mental Health
Associations between related factors and neurotransmitter pathway gene polymorphisms and child
attention deficit hyperactivity disorder
Yu-Kai Du and Dan Hu
Huazhong University of Science and Technology, China
Objective:
Related social factors and neurotransmitter pathway gene polymorphism of child Attention Deficit-Hyperactivity
Disorder (ADHD) was investigated to provide evidence for ADHD prevention and control and clue for further ADHD genetic study.
Methodology:
In the case-control study, social information of 233 ADHD children and 711 health children were investigated
by a self-designed questionnaire. Blood samples of 168 ADHD children and 233 health children were collected. 10 Single
Nucleotide Polymorphisms (SNPs) of
SLC6A3, DRD4, SLC6A2
and
ADRA2A
were tested.
Findings:
In multiple logistic regression, ADHD were related to male (OR=4.96, 95% CI: 3.28-7.49), 6-9 years old (OR=1.77, 95%
CI: 1.24-2.53), family month income ≤3000 yuan per capita (OR=1.85, 95% CI: 1.31-2.61), preterm birth (OR=3.09, 95% CI: 1.15-
8.33), mother general or poor mood (OR=1.67, 95% CI: 1.18-2.36) and indirect smoking (OR=1.81, 95% CI: 1.20-2.72) during
pregnancy, general or poor parents relationship (OR=1.92, 95% CI: 1.31-2.82), father accompany with child <4 hours a week
(OR=1.80, 95% CI: 1.16-2.79), house decoration last year (OR=1.62, 95% CI: 1.03-2.55) and child indirect smoking (OR=1.77,
95%CI: 1.16-2.69). Adjusted for child sex and age,
DRD4 rs747302, DRD4 rs3758653
and
ADRA2A rs521674
polymorphisms were
associated with ADHD, ADHD subtype and ADHD-ODD (all P<0.05).
SLC6A2 rs168924
and
DRD4 rs1800955
polymorphisms
were related to ADHD and ADHD subtype (both P<0.05). There were significant associations between
ADRA2A rs2484516
polymorphisms and ADHD-Inattention (P<0.05), between
SLC6A2 rs40615
polymorphism and ADHD-Hyperactive+Combined
and ADHD-ODD (both P<0.05), and between
rs28386840
polymorphism and ADHD-ODD (P<0.05).
Conclusion:
Boy aged 6-9 years old and preterm children should be screened preferentially for ADHD in order to find ADHD
susceptible children as early as possible. Effects of adverse factors during pregnancy, poor parents and parent-child relationship
and adverse family environment on ADHD are recommended to health education. The polymorphisms of
DRD4 (rs747302,
rs3758653, rs1800955), ADRA2A (rs521674, rs2484516)
and
SLC6A2 (rs168924, rs40615, rs28386840)
may be the potential
functional SNPs related to ADHD and further functional researches are needed.
Recent Publications
1. Du Y K (2016) Genetic variant in CXCL13 gene is associated with susceptibility to intrauterine infection of hepatitis B virus.
Sci Rep
.; 6: 26465.
2. Du Y K (2016) Relationships between plasma leptin levels, leptin G2548A, leptin receptor Gln223Arg polymorphisms and
gestational diabetes mellitus in Chinese population.
Sci Rep
.; 6: 23948.
Biography
Yu-Kai Du has expertise in maternal and child healthcare. He is presently working in Department of Maternal and Child Health, Tongji Medical College, Huazhong
University of Science and Technology. He has undertaken many national natural science funds projects on vertical transmission of hepatitis B virus in the Chinese
population. He has also worked as the Director of Chinese Society of Rural Health, the Director of Standing of Hubei Society of Family Education and Hubei
Society of Comprehensive Development of Children Secretary-General, the Committee of Chinese Maternal and Child Experts’ Committee and the expert group of
prevention of mother-to-child transmission of HIV, China’s Ministry of Health.
duyukai100@aliyun.comYu-Kai Du et al., J Psychiatry 2017, 20:7 (Suppl)
DOI: 10.4172/2378-5756-C1-030