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Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Neurological actions of honeybee products
Hesham El-Seedi
a,b,c
*, Shaden Khalifa
d,e
, Jianbo Xiao
f
, Aida Abd El Wahed
a,b,g
, Lei Chenh Mohamed Farag
i,j
and
Ghulam Abbas
c,k
*
a
Uppsala University, Sweden
b
Menoufia University, Egypt
c
University of Karachi, Pakistan
d
Stockholm University, Sweden
e
Karolinska Institute, Sweden
f
University of Macau, China
g
Agricultural Research Centre, Egypt
h
Fujian Agriculture and Forestry University, China
i
Cairo University, Egypt
j
The American University in Cairo, Egypt
k
Ziauddin University, Pakistan
Statement of the Problem
: According to the World Health Organization, two billion people will be aged 60 years or
older by 2050. Aging is a major risk factor for a number of neurodegenerative disorders. These age-related disorders
currently represent one of the most important and challenging health problems have impact on the economic and
social. Therefore, much attention has been directed towards the design and development of neuroprotective agents
derived from natural sources.
The honeybees (Apis mellifera L.) have several products, including honey, propolis, royal jelly, bee venom, and bee
pollen. Bee products meet the criteria of being natural products that have long-recognized medicinal properties.
Historically, bee products nutritional and medicinal values have been considered for thousands of years by Ancient
Egyptian, Persians, Romans and Chinese in supplementary nutrition and alternative diets. Bee products are often
sold as nutritional supplements and/or health products, and with potential anticancer, antimicrobial activities,
antioxidant, anti-nociceptive, and anti-inflammatory. Bee products polyphenols have neuroprotective actions via
quench biological reactive oxygen species that cause neurotoxicity and aging as well as the pathological deposition
of misfolded proteins, such as amyloid beta.
In the current talk will concerned on the neuroprotective of bee products and its ingredients against neurogernatives
diseases including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis and
depression.
Recent Publications:
1.
Biotech N, Corporation M, Road J, Gung C, Hospital M, Science M, Health, N (2007). Propolin G, a
prenylflavanone, isolated fromTaiwanese propolis, induces caspase-dependent apoptosis in brain cancer cells.
Journal of Agricultural and Food Chemistry, 55: 7366–7376.
2.
Giampieri F, Quiles JL, Orantes-Bermejo FJ, Gasparrini M, Forbes-Hernandez TY, Sánchez-González C,
Battino M (2018). Are by-products from beeswax recycling process a new promising source of bioactive
compounds with biomedical properties? Food and Chemical Toxicology 112:126–133.
3.
Kumar A, Sehgal N, Kumar P, Padi SSV, Naidu P. (2008). Protective effect of quercetin against ICV colchicine‐
induced cognitive dysfunctions and oxidative damage in rats. Phytotherapy Research 22: 1563–1569.
4.
Squillaro T, Schettino C, Sampaolo S, Galderisi U, Di Iorio G, Giordano A, Melone MAB (2018). Adult-onset
brain tumors and neurodegeneration: Are polyphenols protective? Journal of Cellular Physiology, 233:3955–
3967.
Hesham El-Seedi et al., Clin Pharmacol Biopharm, Volume 08