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Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conferenceseries
.com
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Biography
Sherri Smith is experienced in drug metabolism and Pharmacokinetics (DMPK) of small molecules from discovery through clinical development in the
pharmaceutical industry. Recent publication efforts have focused on explaining discrepancies in plasma protein binding values due to interference of plasticizers
commonly used in blood collection bags, to highlight species, ontogeny, and disease state differences in expression of α-1-acid glycoprotein (AAG) and to
provide examples where human PK of drugs have been impacted by preferential binding toAAG. The overall aim is to bring attention to the relevance of accurate
measurement of fraction unbound for the prediction human PK and pharmacodynamics.