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Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Notes:
Page 49
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conference
series
.com
numerically distinct subunit level rearrangements (2017). Scientific Reports 7 (1), 7770, 1-16.
Biography
J Amin laboratory has a primary interest in GABAA and NMDA receptor-channels. We have studied the structure/function relationship of subtypes of GABAA
receptors to enhance our understanding of the molecular mechanism of action of sedative/hypnotic drugs. By co-expression of wild-type with anesthetic-
sensitive subunits of GABAA receptors, we have determined the minimal number of subunits required for orthosteric- versus allosteric-dependent activation of
GABAA receptor channels. The laboratory is also focused on drug discovery with particular interest in ketamine. In the last several years, we have synthesized
a number of ketamine analogues and characterized their molecular actions on the NMDA and GABAA receptors. One oxime analogues of ketamine has shown
great promise in terms of molecular signature on NMDA and GABAA receptors and in an animal model test for antidepressants.