6 / 10
Volume 08
Clinical Pharmacology & Biopharmaceutics
ISSN: 2167-065X
Page 26
August 19-20, 2019 Vienna, Austria
&
7
th
World Heart Congress
24
th
World Congress on
Pharmacology
Pharmacology 2019
World Heart Congress 2019
August 19-20, 2019
JOINT EVENT
conference
series
.com
Shirley Taniguchi, Clin Pharmacol Biopharm, Volume 08
Shirley Taniguchi
University of São Paulo, Brazil
Pharmacological advice for clinical practice
Statement of the Problem
: Treating drugs symptomatically, reversing drug side effects without considering the receptors
involved, and combining drugs without following specific criteria, may result in inefficient attempts to resolve clinical
events.
Methodology & Theoretical Orientation
: This was a retrospective survey of patients hospitalized in a large general
hospital located in the city of São Paulo (Brazil) and individual patients treated at several hospitals in the region.
Findings
: Difficult to control bleeding may occur with the administration of cardiotonic agents (phosphodiesterase
inhibitors) in patients submitted to surgery. Combining anticoagulants with drugs with a high albumin binding rate may
also cause significant bleeding. blockers such as phenytoin without accompanying cardiac function may Intravenous
administration of voltage-dependent sodium channel lead to arrhythmia and difficult to reverse cardiac arrest
Administering depressant drugs to contain akathisia caused by neuroleptics may result in a significant reduction of
consciousness levels. Treating immediate postoperative period opioid hallucinations with typical neuroleptics may cause
motor agitation that could significantly affect the surgical procedure.
Treating L-Dopa hallucinations with neuroleptics may cause motor side effects contributing to the motor difficulties
associated with Parkinson's disease.
Treating confusion with neuroleptics may increase the motor side effects associated with the use of central acting
anticholinesterase inhibitors or cholinergic agonists in patients with Alzheimer's disease.
Conclusion & Significance
: An individualized medical prescription should contain drugs selected based on their
mechanism of action, half life, albumin binding rate, and predicted side effects. This would help reduce risks and increase
the chances of therapeutic success.
Biography
Shirley earned her M.S. in Pharmacology at the University of São Paulo in 1993. From 1994-1996, she worked as a researcher for the Japanese Ministry of
Education in the Department of Pharmacology at the University of Kitasato in Tokyo. She has been an instructor in Pharmacology since 1997 and a researcher
at the Medical School at the University of São Paulo (Faculdade de Medicina /Universidade de São Paulo). Shirley has been teaching undergraduate
Pharmacology classes within Healthcare courses under the theme ‘Education to Prevent the Misuse of Drugs’.Her assistance is requested whenever there is
difficulty associated with the pharmacological treatment in any given sector within different hospitals. Through research projects registered with the Ministry of
Health, Shirley accesses and analyzes medical records to propose pharmacological care to complement patients’ treatments and minimize risks. Shirley has
assisted in research with drugs in the Intensive Care Unit, Urgent Care, sedation in oncology, and in Psychiatry, Geriatrics and Pediatrics departments.