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Volume 8
Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X
Page 42
JOINT EVENT
Pediatric Gastro 2018
Digestive Diseases 2018
October 22-23, 2018
October 22-23, 2018 Berlin, Germany
3
rd
International Conference on
Digestive and Metabolic Diseases
Pediatric Gastroenterology Hepatology & Nutrition
13
th
International Conference on
&
AKT2 expression and 2 years overall survivor in colorectal cancer: A retrospective cohort study
Caroline Saad Vargas
State University of Ponta Grossa, Brazil
Statement of the Problem:
Colorectal cancer(CRC) is one of the most important cancers.There is a great effort to understand
the molecular involvement to predict and counterbalance the odds of metastatic disease. The proto-oncogene serine/threonine
kinase(AKT2) stood out among the studies. The role of AKT isoforms as a whole is already linked to cell proliferation, glucose
uptake, metabolism, angiogenesis and radiation and drug response. The researches with AKT2 have linked its expression
with advanced tumors and metastatic CRC. However, there is a lack of studies comparing the AKT2 expression and Overall
Survivor(OS) in CRC patients yet.This study intends to evaluate the relation between AKT2 expression and 2 years OS among
patients with CRC.
Methods:
140 patients with CRC diagnosed between 2010 and 2015 in a city in Paraná state, Brazil were enrolled for this study.
Primary tumor samples were obtained and analyzed trough immunohistochemistry for expression of AKT2.The clinical data
was retrospective collected frommedical records. Shapiro-Wilk test found a non-Gaussian distribution, hence Mann-Whitney
test was conducted.The authors defined significant a P>0.05.
Findings:
96 patients (68.6%) had a positive 2 years OS.Forty-four(31.4%) had a confirmation of death in the period.The
survivors group had an AKT2 expression varying between 0.6 and 60.3, a 95% confidence interval(CI) of 12.2 and 20.8 and a
median of 17.2.The death group positivity was between 0.9 and 58.9, the 95% CI discreetly higher, between 14.8 and 29.8 and
a 21.8 median.
Conclusion:
The 95% CI and medians obtained were higher among the patients with the death outcome in 2 years.However,
the statistical analysis found no significance in AKT2 expression among the groups(P=0.2378).Therefore, the results suggest
that there is no correlation between the marker expression and 2 years OS in CRC patients.However, it is important to continue
the researches with the AKT2 to check for different results when comparing specific groups of patients.
caroline.saad@hotmail.comJ Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C7-083