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Volume 08
Journal of Alzheimers Disease & Parkinsonism
Parkinsons Congress 2018
May 14-15, 2018
Page 17
Notes:
conference
series
.com
May 14-15, 2018 Singapore
4
th
Global Experts Meeting on
Parkinson’s & Movement Disorders
Neuroprotective and anti-inflammatory role of
Tinospora cordifolia
in MPTP induced parkinsonian
mouse model
P
arkinson’s disease, an age related neurodegenerative disorder, is characterized by progressive loss of dopaminergic neurons
in substantia nigra pars compacta of the mid brain and projecting neurons in striatum. Recently, several studies regarding
parkinson’s disease have proven the role of oxidative stress in neurodegeneration and neuroinflammation. In this context, our
study evaluates the neuroprotective effect of
Tinospora Cordifolia
Aqueous Extract (TCAE) in parkinsonian mice. From the
immunohistochemistry and western blot analysis, it is evident that TCAE inhibits the MPTP-induced activation of NF-κB and
its associated pro-inflammatory cytokines. Through, Real time PCR analysis it was revealed that pro-inflammatory cytokines
were found to be up regulated in MPTP intoxicated mice while TCAE treatment significantly restored their levels. In addition,
the expression level of IL-10 was found decreased in diseased condition which was further restored by TCAE treatment.
Tyrosine hydroxylase, an important enzyme which is used as marker in parkinson’s disease, its expression was found to be
reduced in MPTP mice while on giving TCAE, its level was significantly restored. Our result clearly indicates that
Tinospora
cordifolia
provides neuroprotection against MPTP induced nigrostriatal dopaminergic neurodegeneration and shows potent
anti-inflammatory activity.
Biography
Surya Pratap Singh is currently working as a Professor in the Department of Biochemistry in Banaras Hindu University. He has done his Post-doctoral training from
2000 to 2008 in University of Illinois at Chicago and Johns Hopkins, USA and in 1995-1996 in National Institute of Neuroscience, Tokyo, Japan. He has received
his PhD, MSc and BSc in Faculty of Science, Banaras Hindu University, India.
suryasingh@hotmail.comSurya Pratap Singh
Banaras Hindu University, India
Surya Pratap Singh, J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C2-038