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Page 58

Parkinsons 2016

December 05-07, 2016

Volume 6 Issue 6(Suppl)

J Alzheimers Dis Parkinsonism

ISSN: 2161-0460 JADP, an open access journal

conferenceseries

.com

December 05-07, 2016 Phoenix, USA

2

nd

International Conference on

Parkinson’s Disease & Movement Disorders

Heather R Lucas, J Alzheimers Dis Parkinsonism 2016, 6:6(Suppl)

http://dx.doi.org/10.4172/2161-0460.C1.025

Bioinorganic Implications and Strategies in Parkinson’s Disease

Heather R Lucas

Virginia Commonwealth University, USA

B

rain metal compositions change with aging and with the progression of neurodegenerative diseases. Under oxidatively

stressed conditions, redoxmetals canpromote the generation of free radicals. Alpha-synuclein (αS), the structurally dynamic

protein implicated in Parkinson’s disease (PD) pathology, has shown variable changes in its native biophysical properties in the

presence of redox metals. Such metal promoted αS misfolding and/or post-translational modifications can have detrimental

effects on normal function. The presented research will highlight metal-induced changes in the folding pattern of αS and

the distinguishable differences observed between various metal oxidation states. The aggregation propensity of αS has been

examined by circular dichroism analysis, dynamic light scattering, FT-IR, and thioflavin T fluorescence assays, as well as

through immunoblotting techniques. Another avenue of this research capitalizes on these innate bioinorganic characteristics

to target the dissociation of aggregation prone αS. Macrocyclic metallospecies are being utilized to proteolytically cleave αS

β-sheet fibrils. Thus, the same characteristics that can make aberrant metal-promoted chemistry detrimental, have also been

utilized to affect αS aggregates, as are found in PD Lewy bodies. Through this work, new therapeutic strategies for the treatment

of PD and related disorders may become apparent.

Biography

Heather R. Lucas obtained her Ph.D. in 2009 at the Johns Hopkins University and subsequently carried out research at Osaka University in Japan with the support

of a fellowship through the Global Center of Excellence. She was additionally a Lenfant Biomedical Fellow at the National Heart, Lung and Blood Institute and an

NIH postdoctoral fellow at the National Institute on Aging. Dr. Lucas then joined the faculty within the Virginia Commonwealth University Department of Chemistry

and Chemical Biology Program as an Assistant Professor for the Spring of 2014, where her research group encompasses inorganic biochemistry, biophysics, as

well as inorganic and organic syntheses.

hrlucas@vcu.edu