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.com
September 25-26, 2017 Chicago, USA
3
rd
International Conference on
Parkinson’s disease and Movement Disorders
Volume 7, Issue 5 (Suppl)
J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460
Parkinson 2017
September 25-26, 2017
Comparative study on the potential role of cocoa, epigallocatechin-3- gallate, coenzyme Q10 and
their combination against manganese-induced parkinsonian like syndrome in rats
Azza A Ali
1
, Toqa M Elnahhas
1
, karema Abu-Elfotuh
1
and
Essam Ezzeldin
2
1
Al -Azhar University, Egypt
2
Riyadh, Saudi Arabia
Background:
The worldwide prevalence of Parkinson’s disease (PD) is increasing day by day. It is the most common movement
disorder which occurs due to complex interactions between environmental and genetic factors. There are strong associations
between excessive exposure to Manganese (Mn) and neurodegenerative diseases characterized by extrapyramidal motor
disorder similar to PD. Cocoa is a potent antioxidant and can protect cells against oxidative stress. Epigallocatechin-3-gallate
(EGCG) is responsible for most of green tea’s role in promoting good health with powerful antioxidant, anti-inflammatory and
anti-apoptotic as well as dopaminergic neuroprotective effects. Coenzyme Q10 (CoQ10) is anti-aging and radical scavenger
with effectiveness in improving cognitive disorders.
Objective:
To evaluate and compare the potential effects of Cocoa, EGCG, CoQ10 and their combination against PD induced
by Mn in rats.
Methods:
Rats were divided to 6 groups. One group was normal and 5 groups received daily for 4 weeks MnCl2 (10 mg/
kg IP) either alone or in combination with each of the following: Cocoa (24 mg/kg PO), EGCG (5 mg/kg IP), CoQ10 (200
mg/kg PO) and their combination. Five behavioral tests were used (Grid, Bar, Swimming, Open-field and Y-maze tests). In
addition, biochemical changes in monoamines, AChE, BDNF, GSK-3, Glutamate, GABA, INOS, Cox 2 as well as apoptotic,
neuroinflammatory and oxidative markers were also evaluated besides histopathological examinations.
Results:
Behavioral data showed that Mn induced increase in catalepsy, delay in decision making, disruption in neuromuscular
co-ordination and vigilance as well as decrease in locomotor, emotionality and exploratory activities together with impairment
of spatial memory. All used treatments improved most behavioral impairments however co-administration of Cocoa, EGCG
and CoQ10 showed more pronounced improvements than each one alone. Biochemical and histopathological examinations in
the striatum confirmed the behavioral ones. Cocoa and EGCG showed marked protection from neuronal degeneration in all
brain regions than CoQ10 which still showed some nuclear pyknosis in cerebral cortex and hippocampus.
Conclusion:
Neuronal degeneration as well as behavioral changes induced by Mn was partially improved either by Cocoa,
EGCG or CoQ10 with superiority of EGCG and Cocoa but their combination showed more pronounced protection than each
of them alone.
Biography
Azza A Ali has completed her PhD specialized in Pharmacology and Toxicology from Faculty of Pharmacy, Cairo University, Egypt. Her Postdoctoral studies
included different scientific aspects especially on neurodegenerative disorders. She has also developed research line of behavioral pharmacology in Egypt.
She is Member of many scientific societies such as (AAPS) and Alzheimer's Association (ISTAART). She is also Editorial Board Member of many international
Journals such as
Brain Disorder & Therapy
,
Acta Psychopathologica
,
EC Pharmacology
and
Toxicology
as well as Organizing Committee Member at the 7
th
International Conference on Dementia & Care Practice. She has published more than 50 papers in reputed journals, supervised and discussed more than 80 PhD
and MSc thesis and actively participated by oral and posters presentations at many international conferences especially on Alzheimer's disease and Dementia as
Dementia Conferences 2015, 2016 and Alzheimer's Association International Conference (AAIC 2016). She has many appreciation certificates and certificate of
best presentation award at 19
th
International Conference on Environmental Pollution and Pollution Control (ICEPPC 2017). Now she is the Head of Pharmacology
and Toxicology Department at Al-Azhar University, Egypt.
azzamoro@gmail.comAzza A Ali et al., J Alzheimers Dis Parkinsonism 2017, 7:5 (Suppl)
DOI: 10.4172/2161-0460-C1-031