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conferenceseries
.com
September 25-26, 2017 Chicago, USA
3
rd
International Conference on
Parkinson’s disease and Movement Disorders
Volume 7, Issue 5 (Suppl)
J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460
Parkinson 2017
September 25-26, 2017
J Alzheimers Dis Parkinsonism 2017, 7:5 (Suppl)
DOI: 10.4172/2161-0460-C1-031
Astrocyte iron metabolism is involved in the nigral iron accumulation in Parkinson’s disease
Jun Wang
and
Junxia Xie
Medical College of Qingdao University, China
N
igral iron accumulation plays a key role in Parkinson’s disease (PD). It is worth attention that unlike neurons and other
glia cells, astrocytes have few iron deposit. Our previous results show that 6-hydroxydopamine (6-OHDA) up-regulates
iron import and down-regulates iron export in nigral dopaminergic neurons, thus leading to cellular iron accumulation.
While 6-OHDA promotes iron traffic in astrocytes by up-regulating both iron import and export, thus avoiding iron deposit.
Therefore, astrocytes may be “iron pump”. Then, if the enhanced iron traffic in astrocytes is the source of iron accumulated in
dopaminergic neurons? What is the mechanism of the enhanced iron traffic in astrocytes? In this study, we found that 6-OHDA
that may be produced by auto-oxidation in dopaminergic neurons, promoted iron traffic in astrocytes by the activation of
hypoxia-inducible factors (HIFs) in astrocytes. In addition, it was HIF-2α, but not HIF-1α that regulated the iron transport in
astrocytes. The study is to explore the mechanisms of iron metabolism in astrocytes and its role in the nigral iron accumulation
in PD, thus providing insight into the control of astrocytes function to protect neurons as therapeutic strategies of PD.
junwangqdu@163.com