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Pain Management 2016
October 03-04, 2016
Volume 5, Issue 5(Suppl) J Pain Relief
ISSN: 2167-0846 JPAR, an open access journal
conferenceseries .com
October 03-04, 2016 Vancouver, Canada
International Conference on
Pain Research & Management
Feng Tao, J Pain Relief 2016, 5:5(Suppl)
Effect of psychosocial stress on acute-to-chronic pain transition after surgery
Feng Tao
Texas A&M University Baylor College of Dentistry, USA
C hronic postsurgical pain is a serious issue in clinical practice. After surgery, patients experience ongoing pain or become
sensitive to incident, normally non-painful stimulation. The intensity and duration of postsurgical pain vary. However, it
is unclear how chronic postsurgical pain develops. In this study, we showed that social defeat stress greatly prolonged plantar
incision-induced pain and enhanced plantar incision-induced AMPA receptor GluA1 phosphorylation at the Ser831 site
in the spinal cord. Interestingly, targeted mutation of the GluA1 phosphorylation site Ser831 significantly inhibited stress-
induced prolongation of incisional pain. In addition, stress hormones enhanced GluA1 phosphorylation and AMPA receptor-
mediated electrical activity in the spinal cord. Sub-threshold stimulation induced spinal long-term potentiation in GluA1
phosphomimetic mutant mice, but not in wild-type mice. Therefore, our results suggest that psychosocial stress could induce
acute-to-chronic pain transition after surgery by enhancing AMPA receptor phosphorylation and spinal central sensitization.
Biography
Feng Tao is an Associate Professor in the Department of Biomedical Sciences at Texas A&M University Baylor College of Dentistry, USA. He has received his
RO1 award and Independent Scientist Award from NIH in 2012 and 2014, respectively. He has published more than 30 papers in peer-reviewed professional
journals and is serving as an Editorial Board Member for some professional journals. He has also served as an invited reviewer for Johns Hopkins ACCM Seed
Grant, NSF-sponsored Pilot Funding at Louisiana State University, Arizona Biomedical Research Commission, Britain Israel Research and Academic Exchange
Partnership Regenerative Medicine Initiative, Wings for Life−Spinal Cord Research Foundation in Austria, Department of Veterans Affairs Rehabilitation Research
and Development Service Spinal Cord Injury and Neuropathic Pain Panel, and NIH NRCS Study Section.