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Pain Management 2016
October 03-04, 2016
Volume 5, Issue 5(Suppl) J Pain Relief
ISSN: 2167-0846 JPAR, an open access journal
conferenceseries .com
October 03-04, 2016 Vancouver, Canada
International Conference on
Pain Research & Management
Hichem Khenioui, J Pain Relief 2016, 5:5(Suppl)
Usefulness of intra-articular botulinum toxin injections: A literature review
Hichem Khenioui
Lille Catholic University, France
Background: Botulinum toxin is a proven and widely used treatment for numerous conditions characterized by excessive
muscular contractions. Recent studies have assessed the analgesic effect of botulinum toxin in joint pain and started to unravel
its mechanisms.
Literature Search Methodology: We searched the international literature via the Medline database using the term “intra-
articular botulinum toxin injection” combined with any of the following terms: “knee”, “ankle”, “shoulder”, “osteoarthritis”, and
“adhesive capsulitis of the shoulder”.
Results: Of 16 selected articles about intra-articular botulinum toxin injections, 7 were randomized controlled trials done in
patients with osteoarthritis, adhesive capsulitis of the shoulder, or chronic pain after joint replacement surgery. Proof of anti-
nociceptive effects was obtained in some of these indications and the safety and tolerance profile was satisfactory. The studies
were heterogeneous. The comparator was usually a glucocorticoid or a placebo; a single study used hyaluronic acid. Pain
intensity was the primary outcome measure.
Discussion & Conclusion: The number of randomized trials and sample sizes are too small to provide a satisfactory level of
scientific evidence or statistical power. Unanswered issues include the effective dosage and the optimal dilution and injection
modalities of botulinum toxin.
Biography
Hichem Khenioui is a specialist practising at the Physical Medicine and Rehabilitation Department of Saint Philibert Hospital and teaching at the Catholic University
of Lille. He is an expert on Spasticity Management and Orthopedic Disorders. Pain management is one of his center of interest, in particular, the use of botulinum
toxin injection on neuropathic pain.