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Pain Management 2016
October 03-04, 2016
Volume 5, Issue 5(Suppl) J Pain Relief
ISSN: 2167-0846 JPAR, an open access journal
conferenceseries .com
October 03-04, 2016 Vancouver, Canada
International Conference on
Pain Research & Management
J Pain Relief 2016, 5:5(Suppl)
Gut-the Trojan horse in remote organs’ autoimmunity
Aaron Lerner
Technion-Israel Institute of Technology, Israel
Human beings assemble and maintain a diverse but host-specific gut microbial community along the longitudinal axis of
the intestines. Helped by a functional tight junction, the default response to commensal microbes is tolerance, whereas
the default response to pathogens is an intricately orchestrated immune response, resulting in pathogen clearance. Nutrients
and industrial food additives were suggested to impact the intestinal ecosystem and to breach tight junction integrity, thus,
contributing to autoimmunogenesis. Taken together, certain nutritional components, increased intestinal permeability, disease
specific dysbiotic pathobionts and their capacity of post translation modification of proteins and their secreted metabolites
are luminal events that impact autoimmunity. The current presentation expands on the multi gut originated axes and their
relationship to remote organ autoimmune diseases. Brain, joint, bone, endocrine, liver, kidney, heart, lung and skin autoimmune
diseases are connected to the intestinal luminal compartmental deregulated events to form the gut-systemic organs axes.
Multiple brain functions, sensations, behavior and human mood originate from the intestinal lumen and traffic bi-directionally
between the two organs, impacting the gut-brain axis.
Qualitative phytochemical screening and evaluation of anti-inflammatory, analgesic and antipyretic
activities of Microcos paniculata barks and fruits
Abdullah Aziz
Jessore University of Science and Technology, Bangladesh
Methanolic extracts of Microcos paniculata bark (BME) and fruit (FME) were qualitatively evaluated for phytochemical
constituents, as well as to evaluate their anti-inflammatory, analgesic and antipyretic activities. Phytochemical constituents
of BME and FME were determined by different qualitative tests such as Molisch’s test, Fehling’s test, alkaloid test, frothing
test, FeCl3 test, alkali test, Salkowski’s test and Baljet test. The anti-inflammatory, analgesic and antipyretic activities of the
extracts were evaluated through proteinase-inhibitory assay, xylene-induced ear edema test, cotton pellet-induced granuloma
formation in mice, formalin test, acetic acid-induced writhing test, tail immersion test and Brewer’s yeast induced pyrexia in
mice. M. paniculata extracts revealed the presence of carbohydrates, alkaloids, saponins, tannins, flavonoids and triterpenoids.
All of the extracts showed significant (P<0.05, vs. aspirin group) proteinase inhibitory activity, whereas the highest effect
elicited by plant extracts was exhibited by the BME (75.94% proteinase inhibition activity). Each extract at the doses of 200 and
400 mg/kg body weight showed significant (P<0.05, vs. control) percentage inhibition of ear edema and granuloma formation.
These extracts significantly (P<0.05, vs. control) reduced the paw licking and abdominal writhing of mice. In addition, BME
400 mg/kg, and FME at 200 and 400 mg/kg showed significant (P<0.05, vs. control) analgesic activities at 60 min in the tail
immersion test. Again, the significant (P<0.05, vs. control) post-treatment antipyretic activities were found by BME 200 and
400 mg/kg and FME 400 mg/kg, respectively. Study results indicated that M. paniculata could be a source of plant compounds
with anti-inflammatory, analgesic and antipyretic activities.