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Pain Management 2016
October 03-04, 2016
Volume 5, Issue 5(Suppl) J Pain Relief
ISSN: 2167-0846 JPAR, an open access journal
conferenceseries .com
October 03-04, 2016 Vancouver, Canada
International Conference on
Pain Research & Management
J Pain Relief 2016, 5:5(Suppl)
Spinal 5-HT1A receptor plays a major role in directing serotonergic modulation toward inhibition
on mechanical allodynia of carrageenan inflammation
Jeong Il Choi
Chonnam National University, South Korea
Introduction: Descending serotonergic projectionsmay facilitate or inhibit nociceptive processing in the spinal cord depending
on several factors. Unlike other pain states, spinal 5-hydroxytryptamine 3 receptors (5-HT3R) were shown to play a limited role
in nociceptive transmission of carrageenan-induced inflammatory pain. Instead, a facilitatory role of 5-HT1AR and 5-HT1BR
in spinal nociceptive processing was observed during early-phase of carrageenan model. Although, the maximum release of
5-HT in spinal cord reaches the maximum 2-3 hours after carrageenan injection (early-phase), its release returns to baseline
8 hours.
Aim: To identify the role of Spinal 5-HT1A receptor in directing serotonergic modulation toward inhibition on mechanical
allodynia of carrageenan inflammation.
Methods: Effects of intrathecal (i.t.) nonspecific 5-HTR agonist, subtype agonist or antagonists (5-HT1AR, 5-HT1BR,
5-HT3R), and 5,7-dihydroxytryptamine (5,7-DHT, a serotonergic neurotoxin) on mechanical allodynia were tested for early-
and late-phase allodynia.
Results: Lesioning spinal serotonergic projections with 5,7-DHT induced a significant increase in the intensity of mechanical
allodynia at both early and late-phase. This increase was attenuated by i.t. 5-HT. Also, i.t. 5-HT itself produced a significant
antiallodynic effect in late-phase, but not in early-phase. Similarly, i.t. 5-HT1AR agonist (8-OH-DPAT) attenuated the intensity
of late-phase allodynia in a dose-dependent manner which was antagonized by 5-HT1AR antagonist (WAY-100635), but
produced no effect on the early-phase allodynia. However, other agonists or antagonists of 5-HT1BR and 5-HT3R did not
produce any anti or pro-allodynic effects.
Conclusion: Descending serotonergic modulation plays a vital role in inhibition of nociceptive processing during late-phase
allodynia, which involves spinal 5-HT1A, but not 5-HT1B or 5-HT3 receptors in carrageenan-induced inflammation. However,
the defined role of 5-HT1A and serotonergic inhibition during early-phase remains undetermined.
Pain management techniques
Lolita Mercadié
Wellington Hospital, New Zealand
In the present study, we hypothesized that listening to music would modulate the effects of allodynia, hyperalgesia and fatigue
in patients with fibromyalgia (FM). Due to its emotional effect, we expected that listening to music would have a greater
moderating effect on the perception of pain and fatigue than listening to non-musical sounds. To investigate this hypothesis, we
carried out a study in which people with FMwere given a listening device for four weeks enabling them to listen to either music
or environmental sounds when they experienced pain, in either an active (while carrying out a physical activity) or passive
(at rest) situation, while measuring changes in levels of pain and fatigue. The results of this study indicate that when people
with FM listen to music or environmental sounds when they are at rest, their pain and fatigue decreased after 20 minutes of
listening. This physical improvement persists for ten minutes after the end of the listening session. In physical active situations
their pain did not decrease but it did not increase. Contrary to our expectations, music and environmental sounds produced
the same effect on pain and fatigue, with no extra benefit gained by listening to music rather than environmental sounds.