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Organic Chemistry: Current Research | ISSN: 2161-0401 | Volume 7
July 18-19, 2018 | Atlanta, USA
24th Global
Organic & Inorganic Chemistry Conference
Microwave assisted synthesis of a library of near-infrared molecular probes for in-vivo imaging
Amicrowave-assisted method for the synthesis of a library of Near-Infrared (NIR) molecular probes such as symmetrical
pentamethine cyanines and their corresponding precursors. This class of compounds is advantageous for in vivo imaging
because of the low absorption of biological molecules in the NIR window. The microwave synthesis drastically reduced the
reaction time for dye synthesis from days to min, as well as producing increased yields (89-98%) to the conventional heating
method (18-64%). Also in this study, we demonstrate that it is possible to create tissue-specific (thyroid, salivary, and adrenal
glands) near-infrared fluorophores using the inherent chemical structure. Thus, a single compact molecule performs both
targeting and imaging.
Biography
In 1990, Maged Henary received his BSc. degree in chemistry from Alexandria University and in 2000 he received his Ph.D. degree in organic chemistry from
Georgia State University (GSU) under the supervision of Professor Strekowski. Afterward, he joined Professor Fahrni’s lab at Georgia Institute of Technology. Dr
Henary developed sensors for imaging microscopy of labile zinc and copper pools in live cells. In 2005, he was appointed Lecturer at GSU instructing Undergraduate
classes. In 2011, he accepted a position as Assistant Professor at GSU. His research focuses on the development of heterocyclic compounds, including NIR dyes
for bioanalytical applications.
Maged Henary
Georgia State University, USA
Maged Henary, Organic Chem Curr Res 2018, Volume 7
DOI: 10.4172/2161-0401-C3-027