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Organic Chemistry: Current Research | ISSN: 2161-0401 | Volume 7
July 18-19, 2018 | Atlanta, USA
24th Global
Organic & Inorganic Chemistry Conference
Preparation of novel nucleoside analogues from cyclobutane precursors as potential antiviral agents
C yclobutanes represent strained compounds which exhibit chemical reactivity not encountered with unstrained ring systems.
These properties have been exploited in their capacity as synthetic intermediates. Cyclobutane nucleosides as oxetanocin
analogs have been shown to exhibit antiviral and other biological activities. Our interests in cyclobutanone chemistry has
prompted investigations into the preparation of novel cyclobutane nucleoside analogs. We report in this paper the synthesis of
novel cyclobutanols2 and 3 from its precursor 1. The coupling of 6-chloropurine with 1 gives two regioisomers consisting of the
N-9 and N-7 ketones with the latter formed as the major product.
Biography
Edward Lee-Ruff has received his . and Ph.D. degree from McGill University. He was the NRC Post-Doctoral Fellow Columbia University under Professor
Nick Turro. Since 1969 –present he is a full Professor at York University. He is also a fellow of Chemical Institute of Canada. His main research interest is in
Photochemistry, Mechanisms and Organic Synthesis. He has over 120 publications and 2 patents. Also involved in outreach public presentations on brand name
vs generic pharmaceutical products.
Edward Lee-Ruff
York University, Canada
Edward Lee-Ruff, Organic Chem Curr Res 2018, Volume 7
DOI: 10.4172/2161-0401-C3-027