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conferenceseries
.com
Ophthalmology 2016
November 21-23, 2016
November 21-23, 2016 Dubai, UAE
10
th
International Conference on
Clinical & Experimental Ophthalmology
Volume 7 Issue 9 (Suppl)
J Clin Exp Ophthalmol
ISSN: 2155-9570 JCEO, an open access journal
Bayram Gulpamuk, J Clin Exp Ophthalmol 2016, 7:9(Suppl)
http://dx.doi.org/10.4172/2155-9570.C1.049Thiol/disulphıde homeostasis in patients with keratoconus by a novel assay
Bayram Gulpamuk
Ulucanlar Eyes Training and Research Hospital, Turkey
Purpose:
We aimed to identify serum thiol/disulphide homeostasis between keratoconus patients and controls.
Methods:
28 keratoconus patients and 30 control subjects with similar age and gender were evaluated in the present study. Levels of
native thiol, total thiol and disulphide as well as disulphide/native thiol, disulphide/total thiol, native thiol/total thiol were analyzed
and compared between keratoconus and control groups using a novel automatized spectrophotometric assay.
Results:
There were significant differences between keratoconus patients and the control group for native thiol, total thiol and
disulphide levels (p: 0.001, p: 0.04, p: 0.03, respectively) as well as disulphide/native thiol and disulphide/total thiol and native thiol/
total thiol ratios (p: 0.02, p: 0.01, p: 0.001, respectively). We found no significant correlation between age and all of the thiol/disulphide
parameters (p>0.05, all of the values).
Conclusion:
To best of our knowledge, we have shown for the first time that imbalance of thiol/disulphide homeostasis in keratoconus
patients. This metabolic imbalance of thiol/disulphide may play an important role in the pathogenesis of keratoconus and, so, can be
discussed in prevention, diagnosis and maybe treatment of keratoconus as well.
bfagulpamuk@hotmail.com