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conferenceseries.com
Volume 8 Journal of Obesity & Weight Loss Therapy Obesity Middle East 2018
June 25-26, 2018
June 25-26, 2018 Dubai, UAE
Middle East Obesity, Bariatric Surgery
and Endocrinology Congress
Zyflamend attenuates high fat diet-induced obesity in mice
Mohammed Alquraishi, Dina Alani, Samah Chahed, Tory Frankel, Jay Whelan and Ahmed Bettaieb
University of Tennessee-Knoxville, USA
Obesity is a growing epidemic in the United States, affecting more than one-third of adults. There is also a growing body of
evidence highlighting the contribution of adipose tissue to systemic inflammatory state that play a potent role in obesity-
associatedmetabolic syndrome and cardiovascular diseases. Zyflamend is a poly-herbal supplement derived from the extracts of
ten different herbs effectively activates AMPK in vitro in several cell lines. When activated, AMPK is instrumental in inhibiting
anabolic pathways that consume ATP, such as lipogenesis and protein synthesis and enhances catabolic pathways that generate
ATP, such as fatty acid oxidation. The effects of Zyflamend on adipogenesis remain largely unknown. The objective of this study
was to investigate the effects of Zyflamend treatment on adipogenesis and glucose homeostasis. The report shows the decreased
adipogenesis of mouse and human adipocytes in vitro. Moreover, mice treated with Zyflamend exhibited improved glycemic
control and enhanced insulin signaling in the muscle and adipose tissue compared with control mice. Further, Zyflamend
treatment attenuated chronic HFD-induced Endoplasmic Reticulum (ER) stress in adipose and muscle tissues. Together, these
studies identify Zyflamend as a potential treatment for obesity and metabolic syndrome and additional investigation into the
mechanism(s) of Zyflamend’s metabolic actions.
Biography
Mohammed Alquraishi is a dietician in the Kingdom of Saudi Arabia with the passion of promoting body weight-reduction and maintenance through encouraging
healthy dietary habits. Currently, Alquraishi is a PhD student at the department of Nutrition, University of Tennessee at Knoxville, USA. Alquraishi is working under
the supervision of Dr. Bettaieb to investigate mixture of bioactive compounds, key enzymes, as well as signaling proteins and their contribution to metabolic
diseases such as obesity and type-2 diabetes.
Mohammed Alquraishi et al., J Obes Weight Loss Ther 2018, Volume 8
DOI: 10.4172/2165-7904-C3-063