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Volume 7, Issue 6 (Suppl) J Obes Weight Loss Ther
ISSN: 2165-7904 JOWT, an open access journal Obesity Meeting 2017
October 23-24, 2017
October 23-24, 2017 Dubai, UAE
14th Global Obesity Meeting
Association between β-amino-isobutyric acid and cardiometabolic risk factors
Mirey Karavetian1 , Suzan Haidar2, Nanne de Vries2, Alessandro Laviano3 and Mohammad Rachid 4
1Zayed University, UAE
2Maastricht University, Netherlands
3Sapienza University of Rome, Italy
4Lebanese International University, Lebanon
Physical activity protects from the development of chronic diseases. Preclinical studies suggest that circulating levels of the
myokine β-amino-isobutyric acid (BAIBA) may prevent obesity and improve cardiometabolic health. We aimed at assessing
among healthy young individuals whether serum BAIBA is associated with physical activity, markers of cardiometabolic risk
and whether gender differences exist. The design was cross-sectional, conducted on 80 university students. Anthropometry,
blood pressure, lipid profile, blood glucose, C-reactive protein, cortisol and physical activity weremeasured and analyzed against
serum BAIBA levels. Mean age of the sample was 19.3±2.0 years. BAIBA levels were 1.57±0.61 µM. Males had significantly
larger waist (86.0±9.6 cm), systolic and diastolic blood pressure (124.9±11.7 mmHg and 77.9±9.9 mmHg, respectively),
fasting blood glucose (84.6±7.5 mg/dL), cortisol (594.8±158.9 nmol/L) and physical activity levels than females. They also
had significantly lower HDL (46.9±7.3 mg/dL). BAIBA concentrations in males and females were not significantly different.
No significant association was found between BAIBA concentrations and nutritional, metabolic and functional parameters,
except for diastolic blood pressure (DBP) in males (P=0.03). BAIBA in males predicted DBP as disclosed by ROC curve
analysis. The BAIBA value of 0.97 µM was estimated as the best predictive value in distinguishing normotensive DBP in males
whereby lower levels would distinguish higher diastolic blood pressure. In conclusions, among healthy, young individuals,
serum BAIBA levels were not related to nutritional status, metabolic status and physical activity, but they were inversely related
to DBP in males only.
Biography
Mirey Karavetian has earned her PhD in Health Promotion in Medical Sciences from Maastricht University, Netherlands and her Dietetics degree from American
University of Beirut, Lebanon. She has extensive experience in nutrition management of the chronically and critically ill. Her research is focused on finding effective
strategies to change dietary behavior in chronically ill patients. Her publications focus on dietary management of hemodialysis patients and finding the optimal
dietitian-to-patient ratio needed in the hemodialysis unit in the Arab world for optimal clinical outcomes.
Mirey Karavetian et al., J Obes Weight Loss Ther 2017, 7:6 (Suppl)
DOI: 10.4172/2165-7904-C1-051