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Volume 7, Issue 6 (Suppl)
J Obes Weight Loss Ther
ISSN: 2165-7904 JOWT, an open access journal
Obesity Meeting 2017
October 23-24, 2017
October 23-24, 2017 Dubai, UAE
14
th
Global Obesity Meeting
Retrospective study on the efficacy of antiretroviral treatment after bariatric surgery
Souama Oualid
Université libre de Bruxelles, Belgium
E
ffective antiretroviral treatment offers HIV patients a normal life expectancy. However, as in the general population,
obesity is a recurrent problem in HIV patients, partly due to lipid disorders caused by antiretroviral therapy. Bariatric
surgery may be an option for these patients when diet and exercise are not sufficient, but its safety has not been fully tested
in these patients. This was a monocentric retrospective study held at Saint-Pierre Hospital, Brussels, Belgium. We compared
14 obese HIV affected women (G1) after bariatric surgery, with 45 obese women HIV (G2). A primary outcome was CD4,
CD8, HIV viral load and secondary factors were lipid metabolism, phosphocalcic metabolism and renal function. Patients in
Group-1 (G1) had an average age of 46.07 years and a BMI of 44.11 kg/ m
2
. After performing sets of paired comparisons, testing
differences before and after surgery by means of paired T-tests and paired Wilcoxon signed rank tests, we observed stability in
count CD4, CD8 and HIV viral load, with CD4: before 762±380, after 648±399 with p-value 0.33; CD8: before 737±466, after
828±306 with p-value 0.47 and HIV viral load was 0 before and after surgery; phosphocalcic metabolism, renal function and
lipid metabolism were stable. We compared (G1) to (G2): propensity score was performed; we applied a Bonferroni correction
for multiple comparisons. No differences were found between CD4 count, CD8 count and viral load before and after surgery;
count CD4: 762±380 (G1), 648±399 (G2) with p-value 0.33; CD8: 737±466 (G1), 828±306 (G2) with p=0.47 and HIV viral
load 0 (G1), 5.79±42 (G2) with p=0.21. Secondary outcome was: no differences were observed in Calcium: 2.24 mmoles/
l±0.12 (G1) vs. 2.28±0.12 (G2), p=0.28; Phosphorous: 1.09 mmoles/l±0.15 (G1) vs. 1.16±0.13 (G2), p=0.133; Cholesterol T:
186.43 mg±42.24 (G1) vs. 166.92±19.47 (G2), p=0.078; Triglyceride: 95 mg/l±47 (G1) vs. 124±28 (G2), p=0.009. Fg is the only
variable significantly differing in the two groups under study, with a higher level of Fg observed in the with surgery group
(means=93.79, SD=12.77), compared to the no-surgery group (means=81.36, SD=12.30, adj. P<0.001). Bariatric surgery can
be a safe option for the treatment of obesity in obese HIV patients-stability in CD4, CD8 counts and in viral load in HIV
affected patients was noted, as well as improvement in glomerular filtration. We found no consequences on phosphocalcic and
lipid metabolism.
Biography
Souama Oualid is presently an Anesthesiology Resident at Université libre de Bruxelles, Belgium. He is also an on-call Senior Physician at the Emergency
Department, Tournai and an on-call Senior Physician of Acute Care Unit, Brussels.
michaelange1@yahoo.frSouama Oualid, J Obes Weight Loss Ther 2017, 7:6 (Suppl)
DOI: 10.4172/2165-7904-C1-052