obesity-congress-2016_posters-accepted-abstracts

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Volume 6, Issue 4(Suppl) J Obes Weight Loss Ther
ISSN: 2165-7904 JOWT, an open access journal
Page 50
Notes:
Obesity Congress 2016
August 08-10, 2016
conferenceseries.com
August 08-10, 2016 Toronto, Canada
6th World Congress on
Obesity
Transcranial direct current stimulation changes appetite and body mass in obese rats
Agata Ziomber1, M Szczerbowska-Boruchowska2, E Rokita1 and L Antkiewicz-Michaluk 3
1Jagiellonian University Medical College, Poland
2AGH University of Science and Technology, Poland
3Institute of Pharmacology Polish Academy of Sciences, Poland
Transcranial direct current stimulation (tDCS) is a noninvasive intervention to modulate cortical activity. Electrical current
generated by stimulator modifies neuronal activity according to the modality of the application. Anodal tDCS is assumed to
increase while cathodal tDCS to inhibit cortical excitability. tDCS is effectively used in many different tasks such as learning,
visual and somatosensory functions improving these skills. However, the impact of tDCS on energy balance was not clearly
determined yet. The hyperphagia/ obesityis characterizedby restorationof the balancebetweenbrain hemispheres.Thereforewe
aimed in our experimentto limit appetiteand thereforebodyweightgain by the electricalstimulationor inhibitionof the selected
brainhemisphere by using the tDCS method. The rats fed with diet inducing obesity were exposed to anodal or cathodal tDCS.
Active stimulation (400uA, 20 minutes a day) or sham stimulation (40uA, 20 minutes a day) was applied every second day
through two weeks. Body weightand food intakeweremeasuredeveryday duringthe experiment.Bothanodaland cathodaltDCS
reduced appetite and body weight gain. No significant difference in energy balance was observed depending on electrodes
polarity; however, only in anodal tDCS the differencebetweenbody weightsmeasuredbefore and after stimulationwas negative.
We concludedthat tDCS is able to change appetitebehaviorprobablyby corticalexcitabilitymodifications.Furtherinvestigations
are necessaryto explaincentral and peripheral mechanisms responsible for tDCS effects.
"Founding support of the study was provided by the National Science Centre Poland, grant number DEC-2013/09/B/NZ4/02539"
Biography
Agata Ziomber has completed her PhD from Jagiellonian University and Post-doctoral studies from Jagiellonian University Medical College. She is an Assistant
Professor of Departmentof Pathophysiologyin JagiellonianUniversityMedical College and a medical Doctor - Endocrinologist.She has published 20 articles. In her
researchshe is focusingon neuromodulationas a method to modulateappetiteand changebody weight. At present,she is a Leader of a project regardingtranscranial
brain stimulation and energy metabolism.
Agata Ziomber et al., J Obes Weight Loss Ther 2016, 6:4(Suppl)