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conferenceseries.com
February 20-21, 2017 Berlin, Germany
9th International Congress on
Nutrition & Health
Volume 7 Issue 1 (Suppl) J Nutr Food Sci
ISSN:2155-9600 JNFS, an open access journal Nutrition & Health 2017
February 20-21, 2017 Berlin, Germany
Vitamin A deficiency promotes inflammation by induction of type 2 cytokines in experimental ovalbumin-
induced asthma murine model
Dong Li and Weiwei Cui
Jilin University, China
Statement of the Problem: Vitamin A (VA) deficiency is one of the most common malnutrition conditions. Recent reports showed
that VA plays an important role in the immune balance, lack of VA could result in enchanted type 2 immune response characterized
by increased type 2 cytokines production and type 2 innate lymphoid cells infiltration and activation. Type 2 immune responses plays
protective role in anti-infection, but plays pathological role in asthmatic disease.
Methodology &Theoretical Orientation: In order to investigate the role of VA in the asthmatic disease, we used ovalbumin-induced
asthma murine model, and observed the pathological changes between mouse received VA-deficient and -sufficient diets. We also
measured the type 2 cytokine expressions to reveal the potential mechanism.
Findings: Our results showed that VA deficiency exacerbates ovalbumin-induced lung inflammation via induction of the type 2
cytokine productions.
Conclusion & Significance: VA deficiency, or malnutrition in further extent, may contribute to the increasing prevalence of asthma.
Biography
Dong Li has done his PhD in Immunology from University of Glasgow in 2014. His research interest is to identify the key factors in immune regulation which control
the development of allergy and inflammatory diseases. Current focus is on the role of cytokines IL-1 family members in the mucosal immune system related
diseases as well as how nutrition status influences these key immune regulatory factors.
Dong Li et al., J Nutr Food Sci 2017, 7:1 (Suppl)