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Page 33
Notes:
conferenceseries
.com
February 20-21, 2017 Berlin, Germany
9
th
International Congress on
Nutrition & Health
Volume 7 Issue 1 (Suppl)
J Nutr Food Sci
ISSN:2155-9600 JNFS, an open access journal
Nutrition & Health 2017
February 20-21, 2017 Berlin, Germany
Novel extended-release formulation of
Monascus
fermented rice extract (RYR)
Consumi M, Leone G, Pepi S
and
Magnani A
University of Siena, Italy
M
onascus
fermented red rice (RYR) has been demonstrated to lower cholesterol in blood and sold over-the-counter as an
alternative to cholesterol-lowering statin drugs, especially for who stop statin drugs due to their side effects.The goal of this work
is to develop an extended-release formulation that able to maintain the activity effect against cholesterol, obtaining a constant release
of statins present in RYR throughout the staying of the tablets inside the intestine. This study focus on the analysis of different carriers
for controlled release systems composed by polysaccharide-based matrices by two different formulations based on K-carrageenan
and gellan gum (ranging from 10% to 90% in weight). Samples as cylindrical tablets have been physico-chemical characterized by
FTIR, DSC, TGA, Rheometer and TOF-SIMS, water uptake, water bond, water diffusion and mesoporosity. The Monacolin K release
has been monitored until 48 hours in simulated intestinal fluid SIF. HMG-CoA reductase activity has been measured to determine the
formulation influence on statin activities against the lovastatin activity used as control. The selected formulation enhances the statins
release respect to the RYR matrix alone and, in addition, the preliminary biological results suggest that the activity of these samples is
associated with the inhibition of HMG-CoA reductase. It can be concluded that, release tests pointed out that formulations obtained
combining polymers in a ratio close to 1 (i.e., 40/60 and 50/50) guaranteed a potentiated release of lovastatin from RYR inducing
also a superior hypocholesterolemizing action both in terms of hepatocytes cholesterol production and inhibitory activity towards
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA). The most effective one, in hypocholesterolemizing activity, in
terms of inhibitory activity versus HMG-CoA reductase and hepatocytes cholesterol production, was the formulation obtained
combining 40% of k-carrageenan and 60% of gellan gum
.
Biography
Consumi M is a Research Scientist at University of Siena in the Department of Biotechnology, Chemistry and Pharmacy. He received his PhD in Biomaterials from
University of Trento and has studied polymers and polymer based materials for controlled release of active substances in pharmaceutical and nutraceutical field.
As a Post-doctoral Fellow, he focused on understanding the correlation between the chemical composition of materials and their biological activity. He has broad
expertise in synthesis, modification and characterization of polymers (naturals and synthetics) and materials for biomedical applications. Actually, he is involved in
2 EU ITN projects in bacterial infection topic to fundamentally better understand the biology, chemistry and physical properties of biofilms.
marco.consumi@gmx.comConsumi M et al., J Nutr Food Sci 2017, 7:1 (Suppl)
http://dx.doi.org/10.4172/2155-9600.C1.038