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conferenceseries.com
February 20-21, 2017 Berlin, Germany
9th International Congress on
Nutrition & Health
Volume 7 Issue 1 (Suppl) J Nutr Food Sci
ISSN:2155-9600 JNFS, an open access journal Nutrition & Health 2017
February 20-21, 2017 Berlin, Germany
Lyubov L Kuchkarova et al., J Nutr Food Sci 2017, 7:1 (Suppl)
Correcting effect of some biological substance on digestive disorders at heavy metal intoxication
Lyubov L Kuchkarova, Gulchekhra T Kudeshova, Bekzod M Mirzaev and Nozigul F Kiyomova
National University of Uzbekistan, Uzbekistan
Statement of the Problem: It is known that increasing of heavy metal pollution is correlated with increasing of gastrointestinal
diseases. This suggests the need to find ways to mass prevention and/or correction of digestive disorders at heavy metal intoxication,
especially in industrial regions. The purpose of current study is testing some of the biological substrates to correct heavy metal caused
digestive disorders.
Methods: Morphological and functional characteristics of the gastrointestinal tract have been obtained during multiple experiments
with administration of biologically active substances to intoxicated with heavy metal laboratory animals.
Findings: Аcute toxicity of cadmium, lead and/or mercury ions results in adaptive shifts in the pancreatic and intestinal enzyme
activity to preserve energy homeostasis. Chronic intoxication with heavy metals leads to the development of pancreatitis, diabetes,
malabsorption and other digestive disorders. For the prevention and/or correction of heavy metal intoxication among the tested
biological substrates (flavonoids, terpenoids and non-starch polysaccharides) the most effective were non-starch polysaccharides
(chitosan, inulin and pectin).
Conclusion: These data suggest that adding non-starch polysaccharides in the diet may promotes the correction of pathological
changes in the gastrointestinal tract in heavy metal-contaminated areas.
Biography
Lyubov L Kuchkarova has explored the impact of different exogenous (hormones, xenobiotics, immobilization, malnutrition, overheating, etc.) and endogenous
(hormones) factors on the formation of hydrolytic and transport systems of the digestive system of a growing organism for 30 years. Currently, she is engaged in
search of eсologically acceptable biologically active compounds to correct shifts caused by various Xenobiotics in gastrointestinal tract. In addition, she is the Head
of the Health Club at the National University of Uzbekistan, where special attention is paid to healthy nutrition. She is also the author of number of textbooks and
manuals on the Physiology of Digestion and Nutrition for students.