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Volume 6, Issue 6 (Suppl)
OMICS J Radiol, an open access journal
ISSN: 2167-7964
Neuroradiology 2017
October 30 to November 01, 2017
October 30 to November 01, 2017 | San Antonio, USA
2
nd
International Conference on
Neuroscience, Neuroimaging & Interventional Radiology
Oxidative stress and neuroinflammation in schizophrenia detected by novel neuroimaging approaches
Fei Du
McLean Hospital-Harvard School of Medicine, USA
S
chizophrenia (SZ) is a common and severe psychiatric disorder characterized by abnormal cognition and perception. Despite
its public health impact and a century of biological research, the pathophysiology of SZ remains poorly understood. Recently
accumulated evidence suggests that an immuno-oxidative pathway including oxidative stress, NMDAR hypofunction and
neuroinflammation may contribute to disruptions in brain circuits in SZ. The redox pair of Nicotinamide adenine dinucleotide
(NAD+) and its reduced form NADH have long been implicated in biological activities such as cellular energy metabolism, calcium
homeostasis, gene expression and immunological functions. Despite the crucial roles of NAD+ and NADH in cellular metabolism
and physiology, its non-invasive in vivo detection is extremely challenging. Recently we demonstrate the feasibility of 31P MRS-based
NAD quantification at 4 T MRI-scanner and apply this novel method in patients with SZ. We found a substantial and significant
reduction in the redox ratio (i.e., NAD+/NADH) in the chronic and first-episode SZ patients. Intracellular redox ratio is influenced
by multiple cellular signaling events and may constitute a metabolic integrator for local metabolic status within cells. Therefore, our
work provides new insights into the pathophysiology of SZ, as well as a biomarker for tracking the impact of treatment interventions.
In addition, the identification of pharmacological compounds acting on brain redox status as an innovative therapeutic approach
for first-episode psychosis treatment and neuroimaging biomarker measurements such as glutathione (antioxidant) and glutamate/
glutamine (index of NMDAR hypofunction) will be discussed.
fdu@mclean.harvard.eduOMICS J Radiol 2017, 6:6, (Suppl)
DOI: 10.4172/2167-7964-C1-019