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Volume 8, Issue 2 (Suppl) J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal Neurology 2017
March 27-29, 2017
March 27-29, 2017 Madrid, Spain
11th World Congress on
Neurology and Therapeutics
Aripiprazole does not attenuate the benefits of environmental enrichment after experimental brain trauma
Anthony E Kline
University of Pittsburgh, USA
Introduction: The typical antipsychotic drug (APD) haloperidol (HAL), a D2 receptor antagonist, has been shown to impede
functional outcome after experimental traumatic brain injury (TBI). Furthermore, the deleterious effects persist for up to 3 months
after drug withdrawal. Moreover, a recent study showed that HAL reduced the effectiveness of environmental enrichment (EE), a
preclinical model of neurorehabilitation. Because agitation is common after TBI, patients are provided APDs so that they can be
safely managed. However, many patients in rehabilitation will only experience agitation occasionally and thus will receive APDs
intermittently.
Hypotheses: Aripiprazole (ARIP), a partial D2 receptor agonist, will not impair recovery or reduce the effectiveness of EE regardless
of whether administered once every day (i.e., chronic agitation) or once every other day (occasional agitation).
Methods: Anesthetized adult male rats received a cortical impact of moderate severity or sham injury and were then randomly
assigned to EE or standard (STD) housing. Treatments with ARIP (0.1 mg/kg; i.p.) or vehicle (VEH; 1.0 mL/kg; i.p.) began 24 hr after
injury and continued once daily for 19 days, or once every other day for the same period. Motor and cognitive outcome were assessed
on post-operative days 1-5 and 14-19, respectively.
Results: Motor and cognitive function was significantly improved in the TBI+EE+VEH vs. TBI+STD+VEH group (p<0.05).
Moreover, the TBI+EE+ARIP groups, regardless of dosing regimen, performed significantly better on all endpoints relative to the
TBI+STD+VEH controls (p<0.05), but did not differ from one another or from TBI+EE+VEH (p>0.05).
Conclusions: ARIP, unlike HAL, did not impair recovery or reduce the efficacy of EE, which supports the hypothesis.
Significance: ARIP is beneficial on its own and does not negate the benefits of rehabilitation (i.e., EE) and thus may be used to control
TBI-induced agitation and aggression without compromising recovery.
Biography
Anthony E Kline, PhD, is a Professor in the Departments of Physical Medicine and Rehabilitation, Critical Care Medicine, and the Safar Center for Resuscitation Research
at the University of Pittsburgh. His research includes neurobehavioral recovery and learning after Traumatic Brain Injury (TBI). Therapeutic strategies that include pharma-
cotherapy and environmental enrichment are utilized alone or in combination in an attempt to restore function and/or attenuate TBI-induced deficits. Another interest is the
evaluation of pharmacological agents that may alter TBI and to elucidate potential mechanisms for the observed effects.
Anthony E Kline, J Neurol Neurophysiol 2017, 8:2 (Suppl)