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conferenceseries
.com
Volume 3
October 03-04, 2018 Osaka, Japan
Pediatric Neurology & Medicine
3
rd
International conference on
N
euroscience
, N
euroradiology
and
I
maging
Neuroimaging 2018
October 03-04, 2018
J Pediatr Neurol Med 2018, Volume 3
DOI: 10.4172/2472-100X-C1-003
Parkinsonism and cerebellar ataxia and colon adenocarcinoma in anti-Ma2-associated atypical
encephalitis
Rajib Dutta
West China Hospital, China
A
nti-Ma2 antibody-associated encephalitis, which usually occurs in young men with germ cell tumors of the testis with
features of encephalitis, it can also present in elderly females with basal ganglia disorder features like Parkinsonism and
cerebellar ataxia in absence of limbic or brainstem or diencephalic encephalitis. Patients may not present with any form or
symptoms of encephalitis but the treatment response rate with steroids, IVIG, plasmapharesis to control the initial symptoms is
very high and after resection of the tumor all the symptoms can be totally cured. So, even there is no evidence of tumor on basic
contrast CT/MRI scans, other special imaging like FDG-PET or highly advanced tumor searching imaging plus serum tumor
markers of different tumors should be considered as the tumor spectrum associated with anti-Ma 2 antibody encephalitis is
huge and resection of the tumor can totally cure the patient. A 68-year-old female presented to our department with resting
tremor of right hand for 2 years. After 6 months, resting tremor gradually involved her right leg. Antiparkinsonian drugs were
initiated but her symptoms worsened gradually. Since last 3 months, she developed features of imbalance with occasional falls
and a weight loss of 10 kg. Neurological examination showed features of Parkinsonism. Brisk DTR right side more than left
with abnormal cerebellar signs CE MRI mild atrophy of cerebellum. Anti-Ma2 antibodies in serum and CSF positive, serum
cancer antigen 72-4 were elevated. A sigmoid colon mass was discovered by colonofiberoscopy and adenocarcinoma was
diagnosed via tissue biopsy. Steroids, IVIG and resection of the tumor completely cured the disease. Parkinsonism or cerebellar
ataxia as main component of anti-Ma2-associated encephalitis was rarely reported. Colon adenocarcinoma was rarely reported
in this disease. Response rate to treatment was relatively very high.
rajibdutta808@gmail.com