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Clinical Microbiology: Open Access | ISSN: 2327-5073 | Volume: 7
Microbiology: Education, R&D and Market
7
th
Annual Summit on
September 28-29, 2018 | San Antonio, USA
Pathogen prevalence comparison between cystic fibrosis patients with and without cystic fibrosis-related
diabetes
David Chattin
and
Mirna Ayshoa Al Gabara
National Jewish Health, USA
C
hronic respiratory tract infection leading to respiratory failure is the major cause of morbidity and mortality for patients
with cystic fibrosis (CF). Pathogens causing infective exacerbations must be treated appropriately to minimize lung
function attrition. Two distinct patient populations were compared to identify trends in recognized pathogens isolated from
lung secretions: CF patients with a diagnosis of CF-related diabetes (CFRD) and CF patients without CFRD. Electronic medical
records from 2008-2017 were scrutinized, and 4,157 bacterial isolates from 5,324 cultures performed on 88 patients with CFRD
were compared to 17,766 isolates from 23,831 cultures from 722 patients without CFRD. Identification of microorganisms was
performed using standard clinical microbiology techniques in accordance with guidelines published by the Cystic Fibrosis
Foundation in a medical laboratory accredited by the College of American Pathologists. Patients with CFRD had a 7% higher
probability of having an organism recognized as a respiratory pathogen isolated than patients without CFRD, but CFRD
patients had nearly twice the chance of being infected with
Burkholderia cepacia
, the organism often attributed to end-stage CF
disease (growth in 4.3% of cultures from CFRD patients vs. growth in 2.2% of cultures from non-CFRD patients). The findings
from this study raise the question of whether or not the CFRD disease state impacts the probability of a patient becoming
infected with
B. cepacia
specifically, and what, if any, are the mechanisms of that process. One possible explanation for these
results is the correlation between increasing age and higher prevalence of diabetes and the established evidence that age is
usually higher when CF patients become infected with
B. cepacia
. Due to the impact, a diagnosis of
B. cepacia
infection has on
the CF patient, any factors which impede or promote the growth of that organism will have clinical significance.
Biography
David Chattin is working as a Research Scientist in Microbiology Laboratory, National Jewish Health, and Denver.
chattind@njhealth.orgDavid Chattin, Clin Microbiol 2018, Volume: 7
DOI: 10.4172/2327-5073-C3-040