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.com
Volume 8
Medicinal Chemistry
ISSN: 2161-0444
Medicinal Chemistry 2018
June 14-15, 2018
June 14-15, 2018 | Barcelona, Spain
10
th
World Congress on
Medicinal Chemistry and Drug Design
Chemical analysis of gallstones of district Peshawar and Mardan by atomic absorption
spectrophotometer
Abdullah
1
, Muhammad Balal Arian
1
and
Tasneem Gul Kazi
2
1
Abdul Wali Khan University Mardan, Pakistan
2
University of Sind Jamshoro, Pakistan
G
all bladder cancer [GBC] is a highly fatal malignancy. Regions of high prevalence of gallstones [GS] have shown to have
higher rates of GBC, which is now a recognized risk factor for GBC. In these regards, heavy metal toxicity has also been
reported to associate with GBC. It is also known that over the time heavy metals can accumulate in the biliary system and
hence in the GS. An effort therefore at recognizing and avoiding potential risk factors for GBC occurrence is paramount. The
present study was aimed to determine the chemical composition and heavy metal occurrence in gallstones. For this purpose,
Gallstones were collected from patient admitted in Ali medical center and Mardan Medical complex, Mardan for surgical
treatment (cholesistectomy), and also interviewed the GBC patients dietary pattern, nutritional status, lifestyle and non-dietary
habits, a closed ended questionnaire was prepared. Biological samples including blood, hair, nails, were collected from the
patients. We reported quantitative and qualitative chemical analysis of gallstone. The major element involved in the formation
of gallstone is Ca (Calcium), Cholesterol, and the bile pigment, Mn (manganese), Fe (iron), Co (cobalt), Cu (cupper) were
also the minor components of gallstones. These heavy metals determination were carried out with highly sensitive technique
using Atomic Absorption Spectrophotometer (AAS). This study is involved different type of gallstones i.e. cholesterol, pigment
stone, and the missed stone. Results revealed that ratio of cholesterol stone is greater as compared to pigment stone and mixed
stone. Cholesterol level 54% mixed stone 40% and the pigment stone is 6% according to experimental results and also with
contribution of the minor component like Fe, Mn, Co, Cu. A total of 54% of cholesterol gallstones were found in our study with
the female predominance.
abdullahjani875@gmail.comMed chem (Los Angeles) 2018, Volume 8
DOI: 10.4172/2161-0444-C1-040