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Volume 6, Issue 4(Suppl)
OMICS J Radiol, an open access journal
ISSN: 2167-7964
Medical Imaging and Clinical Research 2017
September 11-12, 2017
September 11-12, 2017 | Paris, France
2
nd
World Congress on
Medical Imaging and Clinical Research
Magnetic resonance imaging and post-processing analysis of flexor muscle in Pompe disease
Ala Khasawneh
University of Pécs, Hungary
P
ompe disease is a rare multisystem genetic disorder that is characterized by a deficiency of the lysosomal enzyme acid alpha-
glucosidase and cytoplasmic glycogen accumulation causing damage that leads to muscle weakness. The aim of this study was
to evaluate the muscle MRI pattern of 12 adults with late onset Pompe patients and 12 sex-and age-matched healthy controls (Age
range 19-59). A training procedure was implemented using an exercise dynamometer device; MRI data was used to compare the three
flexor muscles in the lower limb function. MRI data of biceps femoris (BF) muscle, semitendinosus (ST) muscle, semimembranosus
(SM) muscle in exercises over time (base, 30 min, 24 hours) was measured. We performed and quantified T2-weighted (T2-w) data
of flexor muscles, all data were analyzed by using repeated measure ANOVA. According to our results, significantly lower T2 value in
the ST muscle of controls was observed (base=43 ms, 30 min=48 ms, 24 h=43 ms; P<0.05) compared to the patients, but the change
in SM muscle and BF muscle were not significant. In patients, we detected significantly higher T2 value in SM muscle change over
time (base=129 ms, 30 min=132 ms, 24 h=128 ms; P<0.05) compared to the controls, but ST muscle and BF muscle doesn't show
significant change. As a conclusion, we can say that in Pompe patients, the SM muscle can only react to the exercise apparently and
shows us an activity in affected muscle cells, compared to the control SM muscle that does not show any activity that means perhaps
the Pompe disease change the muscle cells structure to interact to the exercise.
Biography
Ala Khasawneh is a Jordanian Doctor. He completed his Diploma in General Medicine (MD) and has been awarded the qualification of a Physician and title of
Doctor of Medicine from National Pirogov Memorial Medical University. He worked in Basma Hospital, Jordan. Currently, he is a PhD fellow in Diagnostic Medical
Imaging in Hungary. As a Doctor, his main interest is to create new pathways for improving health care.
alaakhalel@aol.comAla Khasawneh, OMICS J Radiol 2017, 6:4(Suppl)
DOI: 10.4172/2167-7964-C1-013