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Volume 4, Issue 6(Suppl) J Infect Dis Ther
ISSN: 2332-0877 JIDT, an open access journal
Page 51
Influenza 2016
September 12-13, 2016
conferenceseries.com
Influenza
September 12-13, 2016 Berlin, Germany
2nd International Conference on
Comparison of microporous membranes in the concentration process for high- dose influenza
vaccines
Hyeon Jang, Jeong-ha Kwon, Jong-Ho Lee, Youn-Chul Shin, Jae Hoon Moon and Dong Ho Ahn
Green Cross Corporation, South Korea
It is generally known that as people get older, immune responses diminish. A series of studies support the decreased immune response
to influenza vaccination in the elderly might cause severe respiratory complications associated with influenza infection. For this reason,
Fluad (Seqirus) and Fluzone High Dose (Sanofi Pasteur), which were recently approved adjuvanted and high-dose (HD) influenza vaccines,
respectively, are recommended for the elderly as they produce higher SCR and SPR than conventional influenza vaccines.
Especially, manufacturing of HD influenza vaccines need an additional concentration step inwhichmicro-porousmembranes are usually
applied. High concentration of HA (hemagglutinin) and low levels of surfactant residues should be achieved in HD vaccines. To establish the
concentration process, contents of HA and surfactant residues were compared among 3 membranes of different manufacturers(Sartorius,
Merck, and PALL). We found that HA concentration increased proportionally to the concentration factor, and the sequential dilution step
decreased levels of surfactant residues. Meanwhile, cellulose acetate (CA) and polyether sulfone (PES) are commonly used as micro-porous
membrane materials but the characteristics of each material and the interaction between concentrates and membranes may have different
influences on the concentration capability of membranes. In our study, PES showed equivalent capability to CA in concentrating HA,
but 2-fold higher capability than CA in decreasing surfactant conclusion, selection of a more appropriate membrane for the
additional concentration step may provide an opportunity for further improvement of the manufacturing process of high-dose influenza
vaccines.
Biography
Hyeon Jang has completed his Master of Science degree in Medicine from Seoul National University. He has been working as an Associate II (Research Worker) for 2 years
in GCC, a leading pharmaceutical company in ROK.
Hyeon Jang et al., J Infect Dis Ther 2016, 4:6(Suppl)