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Volume 7 Journal of Infectious Diseases & Therapy Infectious Diseases & Endocrinology 2019
February 27-28, 2019
February 27-28, 2019 Tokyo, Japan
Infectious Diseases, Diabetes and Endocrinology
Global Experts Meeting on
Shahnaz Armin et al., J Infect Dis Ther 2019, Volume 7
DOI: 10.4172/2332-0877-C2-062
Carbapenem resistant mechanisms in Pseudomonas aeruginosa: A report from Iran
Shahnaz Armin1, Abdollah Karimi1, Fatemeh Fallah1, Leila Azimi1, Saeed Maham1 and Hossein Samadi Kafil2
1Shahid Beheshti University of Medical Sciences, Iran
2Tabriz University of Medical Sciences, Iran
Pseudomonas aeruginosa is one of most prevalent and important Gram negative bacteria in hospital can cause healthcare
association infection in hospitals. Multi Drug Resistance (MDR) strains for these microorganisms can create drastically
therapeutic challenges. During the last decade, first line antibiotic resistance using for the treatment of Gram negative bacterial
infections are increasing globally and in the recent decade resistant to beta-lactam antibiotics such as carbapenemas as a
broad spectrum antibiotic has become increasingly prevalent. Resistance associated with production of carbapenemase and
also, efflux pump are the important problem in the health care systems. Carbapenemase can hydrolyze all of beta- lactam
antibiotics except Monobactam in some case. Efflux pump can eject different classes of antibiotics to outside of bacteria and
make resistance to them. So, these two important antibiotic resistance mechanisms can lead to appearance of multi drug
resistance P. aeruginosa. This study reports the rate of different important carbapenemase and also increase of gene expression
in efflux pump in P. aeruginosa strains were isolated from some burden cities in Iran.
Biography
Shahnaz Armin is a Specialist of Pediatric Infectious Diseases in Pediatric Infections Research Center, Research Institute for Children Health, Shahid Beheshti
University of Medical Sciences, Tehran, Iran. Her research interest is in Medical Microbiology and also Antibiotic Resistance. Her research group works on national
project about global threating bacteria according to priority of WHO.