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Volume 7
Journal of Infectious Diseases & Therapy
Infectious Diseases & Endocrinology 2019
February 27-28, 2019
February 27-28, 2019 Tokyo, Japan
Infectious Diseases, Diabetes and Endocrinology
Global Experts Meeting on
J Infect Dis Ther 2019, Volume 7
DOI: 10.4172/2332-0877-C2-063
Virulent characteristics of multidrug resistant
E. coli
from Zaria, Nigeria
Igwe J C
1
, Olayinka B O
2
, Ehnimidu J O
2
and Onaolapo J A
2
1
Gombe State University, Nigeria
2
Ahmadu Bello University, Nigeria
M
ost Multi Drug Resistant (MDR)
Escherichia coli
isolates (resistant tomore than 3 classes of antibiotics) exhibit co-virulent
characteristics that contribute to mortality and morbidity as a result of resistance to commonly prescribed antibiotics in
the clinics. This study evaluated phenotypically some virulent characteristics in
E. coli
that contribute to the expressed MDR
properties of
E. coli
using standard microbiological methods. 87
E. coli
isolates were confirmed as
E. coli
from urinary tract
infection and diarrhea patients in selected hospitals in Zaria, Nigeria using Microgene identification kit, out of which 58.6%
(51) were observed to be MDR. Significant number of the MDR isolates (70.6% (36)) were extended spectrum beta-lactamase
producers, 45.1% (23) were resistant to Cefoxitin and produce ampC. While further analysis on the isolates showed that 23.5%
(12) were biofilm producers, 47.1% (24) were hetero resistant to Cefoxitin while 5.9% (3) produced carbapenemase. This study
showed that most MDR
E. coli
from UTI and diarrhea could exhibit more than one virulent characteristic. Hence, isolates
with MDR should be subjected to various tests in other to validate the mechanisms of resistance. This will encourage better
treatment options and good periodic surveillance in prescription and dispensing of antibiotics in clinical settings.
Igwejames42@yahoo.com