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.com
Volume 6
Journal of Infectious Diseases and Therapy
ISSN: 2332-0877
Infection Congress 2018
March 01-02, 2018
March 01-02, 2018 Berlin, Germany
5
th
International Congress on
INFECTIOUS DISEASES
Study of
Neisseria gonorrhoeae
strain antibiotic sensitivity profiles (collected inYaoundé from 2009 to
2014) and determination of reference laboratory (Centre Pasteur, Cameroun) role in the surveillance
of bacterial resistance to antibiotics
C Y Tayimetha
1
, M Kengne
1
and
M C Fonkoua
2
1
Catholic University of Central Africa, Cameroon
2
Centre Pasteur du Cameroun, Cameroon
T
he resistance of
Neisseria gonorrhoeae
to antibiotics as recommended by WHO, poses a real public health problem. Thus,
a study of the sensitivity profiles and the determination of the role of the reference laboratory in the surveillance of this
resistance were carried out in Yaoundé. The aims of this study were to contribute to the therapeutic management of infected
patients with appropriate antibiotics; monitor the resistance of
Neisseria gonorrhoeae
to antibiotics; limit its emergence in
order to preserve the recommended antibiotics. Objectives of the study were to study the susceptibility profiles of Neisseria
gonorrhoeae to antibiotics and to determine the role of the laboratory in monitoring this resistance. This retrospective and
prospective study was carried out at Centre Pasteur of Cameroon from 1st January 2009 to 30th September 2014. It consisted of
isolation of
Neisseria gonorrhoeae
strains from the human genital specimens, identification and determination of their resistance
phenotypes to antibiotics by the diffusion method in agar medium. This highlighted the role of the reference laboratory in
resistance monitoring. A total of 193 strains of gonococci were isolated and identified. The most infected age classes were 20-29
and 30-39. Men were more infected than women (sex ratio 2.01). Several phenotypes of resistance have been described. High
resistance to penicillin G (93.3%), tetracycline (58.5%) and nalidixic acid (17.6%) were observed. Ceftriaxone, azithromycin,
spectinomycin, and chloramphenicol were effective at resistance rates of 1.0%, 2.6%, 3.1% and 7.2%, respectively. The overall
percentage of strains producing penicillinase is 81.1%. Only ceftriaxone is still effective among the two WHO recommended
molecules in Cameroon. The other (ciprofloxacin) should be monitored. As resistances to nalidixic acid (quinolone marker)
have been observed since 2010 and continue to grow up exponentially (25% in 2013 and 50% in 2014). Monitoring
Neisseria
gonorrhoeae
resistances to antibiotics is one of the best strategies to prevent resistances in order to preserve the recommended
molecules. Centre Pasteur of Cameroon is the reference laboratory chosen by the WHO for monitoring the resistance of
Neisseria gonorrhoeae
to antibiotics in Central Africa.
Biography
C Y Tayimetha is currently working as a expertise in microbes and infection biology, at Catholic University of Central Africa, Cameroon.
taycurie@gmail.comC Y Tayimetha et al., J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C1-038