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.com
Volume 6
Journal of Infectious Diseases and Therapy
ISSN: 2332-0877
Infection Congress 2018
March 01-02, 2018
March 01-02, 2018 Berlin, Germany
5
th
International Congress on
INFECTIOUS DISEASES
Pharmacoproteomics of
Aspergillus fumigatus
for identification of novel molecular targets having
application immuno diagnosis and therapy
Rambir Singh
and
Poonam Sharma
1
Bundelkhand University, India
2
Indira Gandhi National Tribal University, India
A
spergillosis has emerged as threat to public health in recent past. Early stage diagnosis of aspergillosis has been difficult.
There are limited options of effective drugs for treatment and invasive infections are always fatal. Importantly, clinical
symptoms of aspergillosis overlap with those of TB. This often leads to misdiagnosis of aspergillosis as TB and wrong treatment.
Hence, early diagnosis of aspergillosis is essentially needed. Currently, available late stage antigen based serological tests have
limited diagnostic efficacy. Hence, there is urgent need for identification of novel molecules of diagnostic and therapeutic
relevance. While working with Indian (ITCC-6604) and German (DAYA) strains of
A.
fumigatus
, we were able to identify 111
cytosolic proteins spots from 2D gels. Out of these 111 protein spots, 66 proteins have been identified on comparison with
available protein databases. Immuno-proteomics studies on these cytosolic proteins showed the presence of highly immuno-
dominant IgG and IgE reactive proteins. Characterizations of these proteins have immense application in immuno-diagnosis
and therapy of aspergillosis.
Biography
Rambir Singh completed his PhD in Biomedical Sciences (Infection Biology) from University of Delhi, India in 2004. After completing PhD, he joined Bundelkhand
University, Jhansi, India, as an Assistant Professor in Biochemistry where currently he is working as Associate Professor in Biomedical Sciences. He is teaching
microbiology, biochemical techniques and natural plant product based drug discovery at undergraduate and postgraduate level. He is working in the research area
of ‘Bioactive molecules from Ayurvedic medicinal plants, health effects of probiotics and proteomics of
Aspergillus fumigatus
.
sehrawat_r@yahoo.comRambir Singh et al., J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C1-038